• merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
  • merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

    产品名称:CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
    产品型号:219676
    A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR- More>>

    merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₇Cl₂N₃O₂S774549-97-2
    描述
    概述 A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
    产品目录编号 219676
    品牌系列 Calbiochem®
    同义词 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
    参考
    参考 Robert, R., et al. 2008. Mol. Pharmacol. 73, 478.
    产品信息
    CAS号 774549-97-2
    形式 White solid
    Hill配方 C₁₉H₁₇Cl₂N₃O₂S
    化学配方 C₁₉H₁₇Cl₂N₃O₂S
    Molar Mass 422.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,06-262,Anti-GAL4 (DNA binding domain) Antibody
下一件merck millipore产品:merck millipore,默克密理博,483125,NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem



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