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merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
产品名称:CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
产品型号:219676
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR- More>>
merck millipore,默克密理博,219676,CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₇Cl₂N₃O₂S 774549-97-2 描述 概述 A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060. 产品目录编号 219676 品牌系列 Calbiochem®
同义词 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline 参考 参考 Robert, R., et al. 2008. Mol. Pharmacol. 73, 478. 产品信息 CAS号 774549-97-2 形式 White solid Hill配方 C₁₉H₁₇Cl₂N₃O₂S 化学配方 C₁₉H₁₇Cl₂N₃O₂S Molar Mass 422.3 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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