merck millipore,默克密理愽
  • merck millipore,默克密理博,219330,β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

  • merck millipore,默克密理博,219330,β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

    产品名称：β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
    产品型号：219330
    The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applica More>>

    merck millipore,默克密理博,219330,β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219330,β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₀Cl₂N₂O₄S108409-83-2
    描述
    概述 A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
    产品目录编号 219330
    品牌系列 Calbiochem®
    同义词 N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide, Wnt Pathway Inhibitor IX
    参考
    参考 Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.
    产品信息
    CAS号 108409-83-2
    形式 Yellow solid
    Hill配方 C₁₃H₁₀Cl₂N₂O₄S
    化学配方 C₁₃H₁₀Cl₂N₂O₄S
    Molar Mass 361.2
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219330,β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,FCMAB201F,Milli-Mark™ Anti-CD57-FITC Antibody, clone TB01
下一件merck millipore产品：merck millipore,默克密理博,218745,Caspase Inhibitor III - CAS 634911-80-1 - Calbiochem


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