- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,218833,Caspase-6 Inhibitor XII, pep419 - Calbiochem
产品名称：Caspase-6 Inhibitor XII, pep419 - Calbiochem
产品型号：218833
The Caspase-6 Inhibitor XII, pep419 controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,218833,Caspase-6 Inhibitor XII, pep419 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₉₉H₁₆₂N₃₀O₂₉S 描述 概述 An 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells. 产品目录编号 218833 品牌系列 Calbiochem®
同义词 Caspase inhibitor, pep419 参考 参考 Stanger, K., et al. 2012. Nat. Chem. Bio. 8, 655. 产品信息 形式 White powder 配方 Supplied as a trifluoroacetate salt. Hill配方 C₉₉H₁₆₂N₃₀O₂₉S 化学配方 C₉₉H₁₆₂N₃₀O₂₉S Molar Mass 2268.6 肽序列 Ac-TEKEKGRLHCVEWTILER-NH2 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O 肽序列 Ac-TEKEKGRLHCVEWTILER-NH2 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,524403,Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MADVN6550,MultiScreen-DV，0.65 µm，无色，非无菌
相关产品
merck millipore,默克密理博,IPVH15150,Immobilon-P 方片膜，PVDF，0.45 µm，15 x 15 cm
merck millipore,默克密理博,MAB4410,Anti-Renilla Luciferase Antibody, clone 1D5.2
merck millipore,默克密理博,324904,Epiregulin, Mouse, Recombinant
merck millipore,默克密理博,124542,氧化型辅酶II ; NADP
merck millipore,默克密理博,524403,Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem
merck millipore,默克密理博,MADVN6550,MultiScreen-DV，0.65 µm，无色，非无菌
merck millipore,默克密理博,4500-0230,Guava Cell Toxicity Kit for Flow Cytometry (EasyCyte Flow Cytometer)
merck millipore,默克密理博,AQ132F,Goat Anti-Rabbit IgG Antibody, F(ab')2, FITC conjugate
merck millipore,默克密理博,CBA017,InnoCyte™ Cell Migration Assay, 24-well plate