merck millipore,默克密理博,208745,Calpain Inhibitor VI - CAS 190274-53-4

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merck millipore,默克密理博,208745,Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem
产品名称：Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem
产品型号：208745
The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

merck millipore,默克密理博,208745,Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

产品介绍

merck millipore,默克密理博,208745,Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

重要规格表

经验配方	CAS号
C₁₇H₂₅FN₂O₄S	190274-53-4

描述
概述	A potent, cell-permeable, reversible inhibitor of calpain (IC₅₀ = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC₅₀ = 15 nM) and L (IC₅₀ = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
产品目录编号	208745
品牌系列	Calbiochem®
同义词	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

参考
参考	Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

参考

Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

产品信息
CAS号	190274-53-4
具有ATP竞争性	N
声明	Sold under license of U.S. Patent 6,551,999
形式	White lyophilized solid
Hill配方	C₁₇H₂₅FN₂O₄S
化学配方	C₁₇H₂₅FN₂O₄S
Molar Mass	372.5
肽序列	4-Fluorophenylsulfonyl-Val-Leu-CHO
可逆	Y
结构配方图像

生物信息
主靶	µ-calpain
主靶IC₅₀	7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO
肽序列	4-Fluorophenylsulfonyl-Val-Leu-CHO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.