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merck millipore,默克密理博,207003,Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
产品名称：Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
产品型号：207003
The Calcineurin Inhibitor VIII, CN585, also referenced under CAS 1213234-31-1, controls the biological activity of Calcineurin. This small molecule/inhibitor is primarily used for Phosphorylation & De More>>
merck millipore,默克密理博,207003,Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₁₉Cl₂N₃S 1213234-31-1 描述 概述 A cell-permeable pyrimidine compound that is shown to inhibit the calcineurin (PP2B)-catalyzed dephosphorylation of RII phosphopeptide (Cat. No. 207008), but not pNPP (Cat. Nos. 4876, 487600, 487655, 487663, 487666), in a reversible, calmodulin-independent, and substrate-noncompetitive manner (IC50 = 3.5 µM; Ki = 3.8 µM), while exhibiting little activity against PP1, PP2A, or PP2C even at concentrations as high as 100 µM. Unlike CsA (Cat. No. 239835) and FK506 (Cat. No. 342500), CN585 does not require Cyp A (Cat. No. 239777) and FKBP family immunophilins for PP2B inhibition, nor does CN585 inhibit the peptidyl prolyl cis/trans isomerase (PPIase) activity of Cyp18, FKBP12 (Cat. No. 325902), and Pin1, although binding studies indicate that CN585 and Cyp18/CsA target a common or overlapping binding sites on the catalytic subunit of PP2B. CN585, at 30 µM, is shown to effectively block NFAT nuclear translocation in HeLa cells, NFAT transcription activity in Jurkat cells (IC50 = 10 µM), as well as IL-2 production in PBMC (IC50 = 13 µM) upon PMA/ionomycin stimulation. 产品目录编号 207003 品牌系列 Calbiochem®
同义词 PP2B Inhibitor VIII, Ca2+/Calmodulin-dependent Protein Phosphatase Inhibitor, 6-(3,4-Dichlorophenyl)-4-(N,N-dimethylaminoethylthio)-2-phenyl-pyrimidine 参考 参考 Erdmann, F., et al. 2010. J. Biol. Chem. 285, 1888. 产品信息 CAS号 1213234-31-1 形式 Beige solid Hill配方 C₂₀H₁₉Cl₂N₃S 化学配方 C₂₀H₁₉Cl₂N₃S Molar Mass 404.4 结构配方图像 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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