merck millipore,默克密理愽
  • merck millipore,默克密理博,14-902,AMPK (α2, β1, γ1) Protein, active, 10 µg

  • merck millipore,默克密理博,14-902,AMPK (α2, β1, γ1) Protein, active, 10 µg

    产品名称：AMPK (α2, β1, γ1) Protein, active, 10 µg
    产品型号：14-902
    Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

    merck millipore,默克密理博,14-902,AMPK (α2, β1, γ1) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-902,AMPK (α2, β1, γ1) Protein, active, 10 µg

    描述
    产品目录编号 14-902
    品牌系列 Upstate
    商名
    • Upstate
    描述 AMPK (α2, β1, γ1) Protein, active, 10 µg
    概述 Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.
    应用
    应用 Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in E. coli cells and activated in vivo.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_006252, NM_006253, NM_002733
    Entrez基因汇总 The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
    基因符号
    • PRKAA2
    • PRKAB1
    • PRKAG1
    蛋白靶 AMPK (α2, β1, γ1)
    纯化方法 Cobalt-agarose
    靶子系列 CAMK
    UniProt编号
    • P54646, Q9Y478, P54619
    UniProt汇总 Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
    Cofactor: Magnesium.
    Enzyme regulation: Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-172 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.
    Subunit structure: Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits.
    Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

    merck millipore,默克密理博,14-902,AMPK (α2, β1, γ1) Protein, active, 10 µg

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