merck millipore,默克密理博,14-791M,PI 3-Kinase (p110α(E542K)/p85α) murine, 250 µg

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Merck Millipore 默克密理愽

描述
产品目录编号	14-791M
品牌系列	Upstate
商名	Upstate
描述	PI 3-Kinase (p110α(E542K)/p85α) murine, 250 µg
概述	Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length.
背景信息	The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).

产品信息
演示	50 mM Tris/HCl pH7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.

应用
应用	Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length.

生物信息
来源	Co-expressed by baculovirus in Sf21 insect cells.
品种	Mouse
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	BC089038
基因符号	PK3CA PIK3CA PI3K
蛋白靶	PI3Kα/p85α
纯化方法	Ni²⁺/NTA-agarose
靶子系列	PI3K/PI4K
UniProt编号	P42337 / P26450 (mouse) P42336 / P27986

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

包装信息
数量	250 µg
包装	Also available in 10 μg size (cat#14-791) and in bulk (cat# 14-791-K).

merck millipore,默克密理博,14-791M,PI 3-Kinase (p110α(E542K)/p85α) murine, 250 µg

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