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描述 产品目录编号 14-591M 品牌系列 Upstate
商名 - Upstate
描述 SHP-1 Protein, 125 µg 概述 N-terminal GST-tagged recombinant human full-length SHP-1 应用 应用 N-terminal GST-tagged recombinant human full-length SHP-1, for use in Phosphatase Assays. 主要应用 - Phosphatase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_080548.3
- NM_002831.4
Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. 基因符号 - HPTP1C
- PTPN6
- SHP-1L
- HCP
- SH-PTP1
- PTP1C
- PTP-1C
- HCPH
- SHP1
- SHP-1
蛋白靶 SHP-1 纯化方法 Glutathione-agarose 靶子系列 Tyr phosphatase UniProt编号 - P29350
UniProt汇总 FUNCTION: SwissProt: P29350 # Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
SIZE: 595 amino acids; 67561 Da
SUBUNIT: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, CD300LF and CD84.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
TISSUE SPECIFICITY: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.
PTM: Phosphorylated on serine and tyrosine residues.
SIMILARITY: SwissProt: P29350 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. & Contains 2 SH2 domains. & Contains 1 tyrosine-protein phosphatase domain.产品使用声明 质量保证 routinely evaluated by dephosphorylation of 100mM DiFMUP 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 125 µg 包装 Also available in 10 μg size (cat#14-591) and in bulk (cat# 14-591-K).
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