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描述 产品目录编号 14-304 品牌系列 Upstate
商名 - Upstate
描述 MKK6/SKK3 Protein, unactive, 50 µg 概述 Recombinant human MKK6, amino acids 4-end, fused at the N-terminus to a Mal-E tag 应用 应用 Unactive, recombinant human MKK6, amino acids 4-end, fused at the N-terminus to a Mal-E tag, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_002758.3
Entrez基因汇总 This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. 基因符号 - MKK6
- MAP2K6
- PRKMK6
- MEK6
- SAPKK3
- MAPKK6
蛋白靶 MKK6 纯化方法 affinity chromatography on amylose resin beads 靶子系列 STE UniProt编号 - P52564
UniProt汇总 FUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
SIZE: 334 amino acids; 37492 Da
SUBUNIT: Interacts with Yersinia yopJ.
TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70C 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,07-732,Anti-HDAC6 Antibody, CT
下一件merck millipore产品：merck millipore,默克密理博,208291,Calcium Chloride, Dihydrate, Molecular Biology Grade - CAS 10035-04-8 - Calbiochem
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