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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-732 Replaces MABE546 品牌系列 Upstate
商名 - Upstate
描述 Anti-HDAC6 Antibody, CT 产品信息 格式 Purified 应用 应用 Anti-HDAC6 Antibody, CT is a Rabbit Polyclonal Antibody for detection of HDAC6 also known as histone deacetylase 6 & has been tested in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 6His-tagged fusion protein corresponding to residues 1031-1215 of human histone deacetylase 6 (HDAC6). 宿主 Rabbit 特异性 HDAC6 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006044.2
Entrez基因汇总 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. 基因符号 - KIAA0901
- HDAC6
- FLJ16239
- JM21
- ORFNames=JM21
- HD6
纯化方法 Protein A purfied UniProt编号 - Q9UBN7
UniProt汇总 FUNCTION: SwissProt: Q9UBN7 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
SIZE: 1215 amino acids; 131431 Da
SUBUNIT: Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.
PTM: Ubiquitinated. Its polyubiquitination however does not lead to its degradation. & Sumoylated in vitro.
SIMILARITY: SwissProt: Q9UBN7 ## Belongs to the histone deacetylase family. Type 2 subfamily. & Contains 1 UBP-type zinc finger.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,14-304,MKK6/SKK3 Protein, unactive, 50 µg
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