- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,124032,Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
产品名称：Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
产品型号：124032
The Akt Inhibitor XIV, also referenced under CAS 1191951-57-1, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>
merck millipore,默克密理博,124032,Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₃₁N₃O₂S₂ 1191951-57-1 描述 概述 A cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8 µM, Ki = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1 µM, Ki = 5.5 µM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC50 = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389 levels. 产品目录编号 124032 品牌系列 Calbiochem®
同义词 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide, PDK1 Inhibitor III, PHT-427 参考 参考 Meuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.产品信息 CAS号 1191951-57-1 形式 White solid Hill配方 C₂₀H₃₁N₃O₂S₂ 化学配方 C₂₀H₃₁N₃O₂S₂ Molar Mass 409.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
上一件merck millipore产品：merck millipore,默克密理博,480275,β-NGF, Human, Recombinant, NSO Cells
下一件merck millipore产品：merck millipore,默克密理博,539744,InhibitorSelect™ 96-Well Protein Kinase Inhibitor Library I - Calbiochem
相关产品
merck millipore,默克密理博,EZHPYYT66K,Human PYY (Total) ELISA
merck millipore,默克密理博,14-632,TSSK2 Protein, active, 10 µg
merck millipore,默克密理博,AP503,Goat Anti-Mouse IgG γ chain Antibody, Species Adsorbed
merck millipore,默克密理博,1951,Bacitracin - CAS 1405-87-4 - Calbiochem
merck millipore,默克密理博,480275,β-NGF, Human, Recombinant, NSO Cells
merck millipore,默克密理博,200487,β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem
merck millipore,默克密理博,MAB846,Anti-Mumps Blend Antibody, fusion protein, clones 570-7A, 570-12G
merck millipore,默克密理博,317505,1,2-Dioctanoyl-sn-glycerol - CAS 60514-48-9 - Calbiochem
