- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-876 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-PKCη (Ser674) Antibody Alternate Names - PRKCH, PKCeta, PKCh, protein kinase C, eta
- PRKCH
- PKCeta
- PKCh
- protein kinase C
产品信息 格式 Affinity Purified 演示 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide). 应用 应用 Anti-phospho-PKCη (Ser674) Antibody is an antibody against phospho-PKCη (Ser674) for use in WB. 主要应用 - Western Blotting
应用说明 Immunoblot Analysis: A 0.35 μg/mL dilution of this lot detected phospho-PKCη (Ser674) in RIPA lysate of PMA-treated Jurkat cells. 生物信息 免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-PKCη (Ser674). 宿主 Rabbit 特异性 Recognizes phospho- PKCη (Ser674). May cross-react with PKCα (ser657) and PKCβI (Ser 661). 同种型 IgG 品种反应性 Human Species Reactivity Note Predicted to cross-react with mouse and rat based on 100% sequence homology, but have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006255.3
Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. 基因符号 - MGC5363
- PRKCH
- PRKCL
- MGC26269
- nPKC-eta
- PKC-L
- PKCL
修改 - Phosphorylation
纯化方法 Affinity Purfied UniProt编号 - P24723
UniProt汇总 FUNCTION: SwissProt: P24723 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
SIZE: 682 amino acids; 77563 Da
TISSUE SPECIFICITY: Most abundant in lung, less in heart and skin.
DOMAIN: SwissProt: P24723 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
DISEASE: SwissProt: P24723 # Defects in PRKCH may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 2 years at -80°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,05-550,Anti-Cdc6 Antibody, clone DCS-180
下一件merck millipore产品：merck millipore,默克密理博,ABT185,Anti-Spectrin beta chain Antibody, erythrocyte
相关产品
merck millipore,默克密理博,ST1604,Anti-ADAMTS1 Mouse pAb (1B8)
merck millipore,默克密理博,MAB1406,Anti-Thy-1.1 Antibody, clone OX-7
merck millipore,默克密理博,371970,HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem
merck millipore,默克密理博,05-550,Anti-Cdc6 Antibody, clone DCS-180
merck millipore,默克密理博,ABT185,Anti-Spectrin beta chain Antibody, erythrocyte
merck millipore,默克密理博,567152,β-Sitosterol - CAS 83-46-5 - Calbiochem
merck millipore,默克密理博,CBL490,Anti-Integrin αV Antibody, clone 13C2
merck millipore,默克密理博,71577,pTriEx™-7 Ek/LIC Vector Kit - Novagen
merck millipore,默克密理博,MABN150,Anti-TAR DNA binding protein-43 Antibody, clone TAR5 2H4