merck millipore,默克密理博,07-808,Anti-phospho-Met (Tyr1349) Antibody

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merck millipore,默克密理博,07-808,Anti-phospho-Met (Tyr1349) Antibody
产品名称：Anti-phospho-Met (Tyr1349) Antibody
产品型号：07-808
This Anti-phospho-Met (Tyr1349) Antibody is validated for use in WB for the detection of phospho-Met (Tyr1349).

merck millipore,默克密理博,07-808,Anti-phospho-Met (Tyr1349) Antibody

产品介绍

merck millipore,默克密理博,07-808,Anti-phospho-Met (Tyr1349) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-808
Replaces	04-1063
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-Met (Tyr1349) Antibody
Alternate Names	c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor) c-Met cmet HGFR RCCP2

产品信息
格式	Affinity Purified
演示	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.

应用
应用	This Anti-phospho-Met (Tyr1349) Antibody is validated for use in WB for the detection of phospho-Met (Tyr1349).
主要应用	Western Blotting

生物信息
免疫原品种	Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Met (Tyr1349).
宿主	Rabbit
特异性	Recognizes Met phosphorylated on Tyr1349
同种型	IgG
品种反应性	Human
Species Reactivity Note	Predicted to cross-react with Mouse and Rat based on complete sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_000245.2
Entrez基因汇总	The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
基因符号	HGFR MET AUTS9 c-Met RCCP2
修改	Phosphorylation
纯化方法	Immunoaffinity purified
UniProt编号	P08581
UniProt汇总	FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. SIZE: 1390 amino acids; 155527 Da SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.