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品种反应性 主要应用 宿主 格式 抗体类型 R, B, Ca, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-757 品牌系列 Upstate
商名 - Upstate
描述 Anti-ACK1 Antibody 产品信息 格式 Affinity Purified 应用 应用 Anti-ACK1 Antibody detects level of ACK1 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 161-175 (KPDVLSQPEAMDDFI) of human ACK1 宿主 Rabbit 特异性 ACK1 (Activated cdc42-associated Kinase 1), also known as TNK2 (Tyrosine Kinase, Non-Receptor, 2) 同种型 IgG 品种反应性 RatBovineCanineHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005781.4
- NM_001010938.1
Entrez基因汇总 This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. 基因符号 - ACK
- TNK2
- p21cdc42Hs
- ACK1
- ACK-1
- FLJ45547
- FLJ44758
纯化方法 Immunoaffinity purified UniProt编号 - Q07912
UniProt汇总 FUNCTION: SwissProt: Q07912 # Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
COFACTOR: Magnesium.
SIZE: 1036 amino acids; 114327 Da
SUBUNIT: Interacts with CDC42. Interacts with activated CSPG4.
SUBCELLULAR LOCATION: Cell membrane (By similarity).
SIMILARITY: SwissProt: Q07912 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. & Contains 1 SH3 domain.产品使用声明 质量保证 Routinely evaluated by immunoblot in RIPA lysates from PC-12 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C from date of shipment 包装信息 数量 100 µL
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