- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-040 Replaces 04-232 品牌系列 Upstate
商名 - Upstate
描述 Anti-HDAC4 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-HDAC4 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC4 also known as Histone deacetylase 4, HD4 & has been tested in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 129-137 of human HDAC4 (C-EHQRKLERH) 宿主 Rabbit 特异性 HDAC4 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006037
Entrez基因汇总 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. 基因符号 - HA6116
- HDAC4
- HD4
- HDAC-A
- KIAA0288
- HDACA
纯化方法 Protein A chromatography UniProt编号 - P56524
UniProt汇总 FUNCTION: SwissProt: P56524 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
SIZE: 1084 amino acids; 119070 Da
SUBUNIT: Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with JARID1B.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN: SwissProt: P56524 The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
PTM: Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3. & Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.
SIMILARITY: Belongs to the histone deacetylase family. Type 2 subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot on mouse brain nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,07-757,Anti-ACK1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,539514,Protein Phosphatase, Lambda, Recombinant, E. coli
相关产品
merck millipore,默克密理博,SF-703,MET; Human, Cyanine 3, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,AB15542,Anti-Myelin Basic protein Antibody
merck millipore,默克密理博,14-505,PKC iota Recombinant Human Protein, Active, 10 µg
merck millipore,默克密理博,558300,SeaBlock™ Reagent, Salmon Plasma
merck millipore,默克密理博,07-757,Anti-ACK1 Antibody
merck millipore,默克密理博,539514,Protein Phosphatase, Lambda, Recombinant, E. coli
merck millipore,默克密理博,MSRLN0450,MultiScreen Solvinert，亲水性 PTFE，0.45 µm，无色，非无菌
merck millipore,默克密理博,MAB880-K,Anti-Influenza A, clone H16-L10-4R5 (1mg)
merck millipore,默克密理博,SF-1556,CD14; Human, Cyanine 5 RNA Detection Probe,SmartFlare
