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merck millipore,默克密理博,07-750,Anti-acetyl-Histone H3 (Lys79) Antibody
产品名称：Anti-acetyl-Histone H3 (Lys79) Antibody
产品型号：07-750
Anti-acetyl-Histone H3 (Lys79) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-Histone H3 (Lys79) also known as H3K79Ac, Histone H3 (acetyl K79) & has been validated in WB, ELISA.
merck millipore,默克密理博,07-750,Anti-acetyl-Histone H3 (Lys79) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-750 品牌系列 Upstate
商名 - Upstate
描述 Anti-acetyl-Histone H3 (Lys79) Antibody Alternate Names - Histone H3 (acetyl K79)
- H3K79Ac
背景信息 Methylation of Lysine 79 in Histone 3 acts as a marker of inactive chromatin regions. Methylation by Dot1 methylase on lysine-79 (Lys79) of Histone H3 is criticial for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation. Likewise, it is predicted that acetylation of Lys79 may indicate active gene transcription. 产品信息 格式 Affinity Purified 控制 - Tested on acid extracted proteins from HeLa cells
演示 Purified rabbit IgG in 70% storage buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide, 5 mg/mL BSA and 30% glycerol. 应用 应用 Anti-acetyl-Histone H3 (Lys79) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-Histone H3 (Lys79) also known as H3K79Ac, Histone H3 (acetyl K79) & has been validated in WB, ELISA. 主要应用 - ELISA
- Western Blotting
应用说明 Western Blot Analysis: A 1:1000-1:2000 dilution detected acetyl-Histone H3 (Lys79) in acid extracts from HeLa cells. Signal is increased in cells treated with sodium butyrate (Catalog # 19-137), a histone deacetylase inhibitor. No detection of recombinant, unmodified human Histone H3 (Catalog # 14-494) was observed.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 KLH-conjugated, synthetic peptide containing the sequence (…DF[acK]TD…) where [AcK] corresponds to acetyl-lysine 79 of human histone H3. 表位 Acetylated Lys79 of Histone H3 宿主 Rabbit 特异性 Recognizes acetyl-Histone H3 (Lys79), Mr 17 kDa. Does not recognize unmodified Histone H3. 同种型 IgG 品种反应性 Human Species Reactivity Note Broad species cross-reactivity expected due to sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003484
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. 基因符号 - MGC87782
- H3F3A
- H3.3B
- H3F3
- MGC87783
- H3F3B
- H3.3A
修改 - Acetylation
纯化方法 Immunoaffinity purified UniProt编号 - Q5KA91
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt. Avoid repeated freeze/thaw cycles.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
包装信息 数量 100 µL
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