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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-503 品牌系列 Upstate
商名 - Upstate
描述 Anti-p40-phox Antibody 产品信息 格式 Purified 演示 Protein A purified antibody in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. 应用 应用 Anti-p40-phox Antibody is an antibody against p40-phox for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 C-terminal 6HIS-tagged fusion protein corresponding to full length human p40-phox 宿主 Rabbit 特异性 p40-phox 同种型 IgG 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_013416
Entrez基因汇总 The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. 基因符号 - NCF-4
- NCF4
- SH3PXD4
- p40-phox
- OTTHUMP00000043756
- MGC3810
- NCF
- P40PHOX
- p40phox
- OTTHUMP00000028736
纯化方法 Protein A purfied UniProt编号 - Q15080
UniProt汇总 FUNCTION: SwissProt: Q15080 # Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
SIZE: 339 amino acids; 39032 Da
SUBUNIT: p40-PHOX associates primarily with p67-PHOX to form a complex with p47-PHOX.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expression is restricted to hematopoietic cells.
SIMILARITY: SwissProt: Q15080 ## Contains 1 PX (phox homology) domain. & Contains 1 SH3 domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates of HL-60 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µg
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