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品种反应性 主要应用 宿主 格式 抗体类型 Eq, H, M, R, Ca WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1530 描述 Anti-PFKFB2 Antibody Alternate Names - Fructose-2,6-bisphosphatase
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
- 6PF-2-K/Fru-2,6-P2ase 2
- PFK/FBPase 2
- 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
- 6-phosphofructo-2-kinase
背景信息 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) is an enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart (a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle) to regulate glycolysis and gluconeogensis. 产品信息 格式 Affinity Purified 控制 - Human heart tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect PFKFB2 using this Anti-PFKFB2 Antibody validated for use in WB & IP. 主要应用 - Western Blotting
应用说明 Immunoprecipitation: A 1:50 dilution of this antibody immunoprecipitated PFKFB2 from 500 µg of PANC1 RIPA lysate 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human PFKFB2. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes PFKFB2 at the C-terminus. 品种反应性 HorseHumanMouseRatCanine Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, Canine, and Equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006203
Entrez基因汇总 The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 基因符号 - PFKFB2
纯化方法 Affinity purified UniProt编号 - O60825
UniProt汇总 FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate.
CATALYTIC ACTIVITY: Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
ENZYME REGULATION: Phosphorylation results in the activation of the kinase activity.
SUBUNIT STRUCTURE: Homodimer (By similarity).
TISSUE SPECIFICITY: Heart.
SEQUENCE SIMILARITIES: In the C-terminal section; belongs to the phosphoglycerate mutase family.产品使用声明 质量保证 Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected PFKFB2 on 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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