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merck millipore,默克密理博,07-1441,Anti-phospho-Paxillin (Ser126) Antibody
产品名称：Anti-phospho-Paxillin (Ser126) Antibody
产品型号：07-1441
Anti-phospho-Paxillin (Ser126) Antibody is an antibody against phospho-Paxillin (Ser126) for use in WB.
merck millipore,默克密理博,07-1441,Anti-phospho-Paxillin (Ser126) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1441 Replaces AB3793 描述 Anti-phospho-Paxillin (Ser126) Antibody Alternate Names - FLJ16691
- paxillin
背景信息 Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. 产品信息 格式 Affinity Purified 控制 - Pervandate treated and untreated Huvec cell lysate
演示 PBS (no Ca2+, no Mg2+), pH 7.3, 50% glycerol, 1 mg/mL BSA, and 0.05% sodium azide. 应用 应用 Anti-phospho-Paxillin (Ser126) Antibody is an antibody against phospho-Paxillin (Ser126) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugagted synthetic peptide corresponding to human Paxillin at phosphorylated Ser126. 表位 Ser126 宿主 Rabbit 特异性 This antibody recognizes Paxillin phosphorylated at Ser126. 品种反应性 MouseHuman Species Reactivity Note Proven to react with human and mouse. Predicted to react with rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002850.2
基因符号 - paxillin
- FLJ16691
修改 - Phosphorylation
纯化方法 Affinity Purfied UniProt编号 - P49023
UniProt汇总 FUNCTION:: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
SUBUNITY STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
PTM:Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
SEQUENCE SIMILARITIES: Belongs to the paxillin family.
Contains 4 LIM zinc-binding domains.产品使用声明 质量保证 Evaluated by Western Blot in pervandate treated and untreated Huvec cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Paxillin on 10 µg of Pervandate treated and untreated Huvec cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to one year or 2-8°C for short term use from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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