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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, IHC Rb Purified Polyclonal Antibody 描述 产品目录编号 07-087 品牌系列 Upstate
商名 - Upstate
描述 Anti-mAKAP Antibody 产品信息 格式 Purified 演示 200 µg protein A purified rabbit IgG in 200 µL of 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide, and 30% glycerol. Frozen solution. 应用 应用 Anti-mAKAP Antibody is an antibody against mAKAP for use in IH, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 His-tagged, recombinant protein corresponding to residues 1666-2319 of human muscle AKAP 宿主 Rabbit 特异性 mAKAP 同种型 IgG 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004274
Entrez基因汇总 The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. 基因符号 - KIAA0311
- AKAP6
- mAKAP
- ADAP100
- PRKA6
- ADAP6
- AKAP100
纯化方法 Protein A purfied UniProt编号 - Q13023
UniProt汇总 FUNCTION: SwissProt: Q13023 # Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
SIZE: 2319 amino acids; 256720 Da
SUBUNIT: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79.
SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
TISSUE SPECIFICITY: Highly expressed in cardiac and skeletal muscle, followed by brain.
DOMAIN:SwissProt: Q13023 RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
SIMILARITY: Contains 2 spectrin repeats.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA cell lysates from L6 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,655206,TWEEN 20, PROTEIN GRADE Detergent, 10% Solution, Sterile-Filtered - CAS 9005-64-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,662089,UCH-L3 Inhibitor - CAS 30675-13-9 - Calbiochem
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