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merck millipore,默克密理博,06-588,Anti-STAT5A/B Antibody
产品名称：Anti-STAT5A/B Antibody
产品型号：06-588
Detect STAT5A/B also known as signal transducer & activator of transcription 5A/B with Anti-STAT5A/B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA.
merck millipore,默克密理博,06-588,Anti-STAT5A/B Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Sh, H, M, R EMSA Rb Serum Polyclonal Antibody 描述 产品目录编号 06-588 Replaces 04-1016 品牌系列 Upstate
商名 - Upstate
描述 Anti-STAT5A/B Antibody 产品信息 格式 Serum 演示 whole rabbit antiserum containing 0.05% sodium azide 应用 应用 Detect STAT5A/B also known as signal transducer & activator of transcription 5A/B with Anti-STAT5A/B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA. 主要应用 - Electrophoretic Mobility Shift Assay
生物信息 免疫原品种 peptide (CQELQKKAEHQVGEDG), corresponding to amino acids 66-80 of human STAT5 A and B 宿主 Rabbit 特异性 STAT5A and B 同种型 IgG 品种反应性 SheepHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003152.2
Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. 基因符号 - STAT5
- STAT5A
- MGF
纯化方法 Antiserum UniProt编号 - P42229
UniProt汇总 FUNCTION: SwissProt: P42229 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SIZE: 794 amino acids; 90647 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.产品使用声明 质量保证 routinely evaluated by Supershift 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 250 µL
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