- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-271 品牌系列 Upstate
商名 - Upstate
描述 Anti-ZAP-70 Antibody 产品信息 格式 Serum 演示 whole rabbit antiserum 应用 应用 Anti-ZAP-70 Antibody detects level of ZAP-70 & has been published & validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to residues 326-341 of human ZAP-70 宿主 Rabbit 特异性 ZAP-70; this antiserum also recognizes bands that migrate below the 66 kDa standard and above ZAP-70. Recognition of these proteins is blocked by preincubating with the immunizing peptide. 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001079
Entrez基因汇总 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. 基因符号 - SRK
- ZAP70
- ZAP-70
- TZK
- STD
纯化方法 Antiserum UniProt编号 - P43403
UniProt汇总 FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.
SIZE: 619 amino acids; 69872 Da
SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).
TISSUE SPECIFICITY: Expressed in T- and natural killer cells.
DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.
PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.产品使用声明 质量保证 routinely evaluated by immunoblot on modified-RIPA lysate of human Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 3 years at -20°C 包装信息 数量 150 µL
上一件merck millipore产品：merck millipore,默克密理博,DR1057,Anti-SQSTM1 Mouse mAb (2C11)
下一件merck millipore产品：merck millipore,默克密理博,05-592,Anti-PP2A Antibody, B subunit, clone 2G9
相关产品
merck millipore,默克密理博,56766,Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem
merck millipore,默克密理博,AB5611,Anti-Neuroketal Antibody
merck millipore,默克密理博,AG546,β amyloid 11-40, rat and mouse
merck millipore,默克密理博,1185-OP,OmniPur Acrylamide Solution, 40% W/V - Calbiochem
merck millipore,默克密理博,DR1057,Anti-SQSTM1 Mouse mAb (2C11)
merck millipore,默克密理博,05-592,Anti-PP2A Antibody, B subunit, clone 2G9
merck millipore,默克密理博,ABN277,Anti-TXN Antibody
merck millipore,默克密理博,524394,4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem
merck millipore,默克密理博,MABC94,Anti-Sphingosine 1-phosphate receptor 1 (S1P1) Antibody, clone 8B7.1
merck millipore,默克密理博,SF-1029,BMPR2; Mouse, Cyanine 5 RNA Detection Probe,SmartFlare