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merck millipore,默克密理博,06-1306,Anti-Mi-2b (CHD4) Antibody
产品名称：Anti-Mi-2b (CHD4) Antibody
产品型号：06-1306
Use Anti-Mi-2b (CHD4) Antibody (rabbit polyclonal antibody) validated in WB to detect Mi-2b (CHD4) also known as ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, chromodomain helicase DN More>>
merck millipore,默克密理博,06-1306,Anti-Mi-2b (CHD4) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-1306 描述 Anti-Mi-2b (CHD4) Antibody Alternate Names - chromodomain helicase DNA binding protein 4
- ATP-dependent helicase CHD4
- Mi-2 autoantigen 218 kDa protein
背景信息 CHD-4 is also often referred to as Mi2-beta. This protein is a central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. CHD4 has been shown to interact with TRIM27, HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related. This protein also interacts with KLF1. This interaction which depends on sumoylation of KLF1 leads to its transcriptional repression. 产品信息 格式 Serum 控制 - HeLa nuclear extract cell lysate
演示 Unpurified rabbit polyclonal in serum with 0.05% sodium azide. 应用 应用 Use Anti-Mi-2b (CHD4) Antibody (rabbit polyclonal antibody) validated in WB to detect Mi-2b (CHD4) also known as ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, chromodomain helicase DNA binding protein 4. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to mouse CHD-4 at and around the N-terminus. 表位 N-terminus 宿主 Rabbit 特异性 This antibody recognizes CHD-4 at the N-terminus. 品种反应性 MouseHuman Species Reactivity Note Proven to react with human. Predicted to react with mouse based on 100% sequence homology. Rat (96%). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_666091.1
Entrez基因汇总 The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. 基因符号 - Mi2-beta
- CHD4
- CHD-4
- Mi-2b
- Mi2-BETA
纯化方法 Unpurified UniProt编号 - Q6PDQ2
UniProt汇总 FUNCTION: Probable transcription regulator by similarity.
SUBUNIT STRUCTURE: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Interacts with ZGPAT; the interaction is direct. Part of a complex containing ATR and HDAC2 By similarity. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression. Interacts directly with IKFZ1 in the NuRD complex.
SUBCELLULAR LOCATION: Nucleus By similarity.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR by similarity.
SEQUENCE SIMLARITIES: Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 2 PHD-type zinc fingers.产品使用声明 质量保证 Evaluated by Western Blot in HeLa nuclear extract cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected CHD-4 on 10 µg of HeLa nuclear extract cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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