merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1102,Anti-Protein patched homolog 1 Antibody

  • merck millipore,默克密理博,06-1102,Anti-Protein patched homolog 1 Antibody

    产品名称：Anti-Protein patched homolog 1 Antibody
    产品型号：06-1102
    Anti-Protein patched homolog 1 Antibody detects level of Protein patched homolog 1 & has been published & validated for use in WB, IH.

    merck millipore,默克密理博,06-1102,Anti-Protein patched homolog 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1102,Anti-Protein patched homolog 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1102
    描述 Anti-Protein patched homolog 1 Antibody
    Alternate Names
    • patched homolog 1 (Drosophila)
    • PTCH protein +12b
    • PTCH protein +4'
    • PTCH protein -10
    • patched (Drosophila) homolog
    • patched homolog (Drosophila)
    背景信息 Protein patched homolog 1 is a receptor for sonic hedgehog, a member of the hedgehog family of cell signaling proteins. Hedgehog signaling is regulated by Protein patched homolog 1 which keeps the pathway turned off in the absences of activation. This inhibits the function of associated downstream network components such as Smoothened (Smo).
    产品信息
    格式 Affinity Purified
    控制
    • Human skeletal muscle, fetal tissue lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Protein patched homolog 1 Antibody detects level of Protein patched homolog 1 & has been published & validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Protein patched homolog 1 in kidney tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Protein patched homolog 1.
    表位 Cytoplasmic domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the cytoplasmic domain of Protein patched homolog 1.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000255
    Entrez基因汇总 This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq].
    基因符号
    • patched
    • PTCH1
    • BCNS
    • HPE7
    • NBCCS
    • PTC
    • PTC1
    • PTCH
    • PTCH11
    纯化方法 Affinity Purfied
    UniProt编号
    • Q13635
    UniProt汇总 FUNCTION: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

    SUBUNIT STRUCTURE: Interacts with SNX17.

    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

    TISSUE SPECIFICITY: In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

    DEVELOPMENTAL STAGE: In the embryo, found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.

    PTM: Glycosylation is necessary for SHH binding By similarity.

    INVOLVEMENT IN DISEASE: Defects in PTCH1 are probably the cause of basal cell nevus syndrome (BCNS) [MIM:109400]; also known as Gorlin syndrome or Gorlin-Goltz syndrome. BCNS is an autosomal dominant disease characterized by nevoid basal cell carcinomas (NBCCS) and developmental abnormalities such as rib and craniofacial alterations, polydactyly, syndactyly, and spina bifida. In addition, the patients suffer from a multitude of tumors like basal cell carcinomas (BCC), fibromas of the ovaries and heart, cysts of the skin, jaws and mesentery, as well as medulloblastomas and meningiomas. PTCH1 is also mutated in squamous cell carcinoma (SCC). Could also be associated with large body size observed in BCNS patients.

    Defects in PTCH1 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462].

    Defects in PTCH1 are the cause of holoprosencephaly type 7 (HPE7) [MIM:610828]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

    SEQUENCE SIMLARITIES: Belongs to the patched family.

    Contains 1 SSD (sterol-sensing) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in human skeletal muscle, fetal tissue lysate.

    Western Blot Analysis: 0.1 µg/ml of this antibody detected Protein patched homolog 1 on 10 µg of human skeletal muscle, fetal tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1102,Anti-Protein patched homolog 1 Antibody

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