merck millipore,默克密理愽
  • merck millipore,默克密理博,05-807,Anti-phospho-CREB (Ser133) Antibody, clone 634-2

  • merck millipore,默克密理博,05-807,Anti-phospho-CREB (Ser133) Antibody, clone 634-2

    产品名称：Anti-phospho-CREB (Ser133) Antibody, clone 634-2
    产品型号：05-807
    Use Anti-phospho-CREB (Ser133) Antibody, clone 634-2 (mouse monoclonal antibody) validated in ICC, IF, WB to detect phospho-CREB (Ser133) also known as active transcription factor CREB, cAMP responsiv More>>

    merck millipore,默克密理博,05-807,Anti-phospho-CREB (Ser133) Antibody, clone 634-2

  • 产品介绍
  • merck millipore,默克密理博,05-807,Anti-phospho-CREB (Ser133) Antibody, clone 634-2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-807
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-CREB (Ser133) Antibody, clone 634-2
    Alternate Names
    • transactivator protein
    • active transcription factor CREB
    • cAMP responsive element binding protein 1
    • cAMP-response element-binding protein-1
    背景信息 CREB is a β ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.
    产品信息
    格式 Purified
    控制
    • Human breast carcinoma, forskolin- and FGF-treated SK-N-MC cell extracts.
    演示 Purified mouse IgG1κ in buffer containing 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide and 30% glycerol. Liquid at -20ºC.
    应用
    应用 Use Anti-phospho-CREB (Ser133) Antibody, clone 634-2 (mouse monoclonal antibody) validated in ICC, IF, WB to detect phospho-CREB (Ser133) also known as active transcription factor CREB, cAMP responsive element binding protein 1.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Beadlyte Specificity Assay:
    1:500 to 1:32,000 dilutions of this lot detected CREB peptide containing phosphoserine 133. The antibody did NOT recognize the nonphosphorylated peptide of the same sequence

    Immunofluorescence / Immunocytochemistry:
    This antibody has been reported by an independent laboratory to detect phospho-CREB (Ser133) using immunofluorescence.
    生物信息
    免疫原品种 A proprietary immunogen based on the amino acid sequence containing phospho-serine corresponding to residue 133 of human CREB.
    表位 Ser133
    克隆 634-2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Phospho-CREB (Ser133).
    同种型 IgG1κ
    品种反应性 RatMouse
    Species Reactivity Note Mouse and rat. Broad species cross-reactivity expected, based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_134442
    Entrez基因汇总 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
    基因符号
    • MGC9284
    • CREB
    修改
    • Phosphorylation
    纯化方法 Protein G purfied
    UniProt编号
    • P16220
    UniProt汇总 FUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
    SIZE: 341 amino acids; 36688 Da
    SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.
    产品使用声明
    质量保证 Routinely evaluated by western blot on RIPA lysates from forskolin treated rat PC-12 and mouse 3T3/A31 cells.

    Western Blot Analysis:
    A 1:1,000 to 1:4,000 dilution of this lot detected phospho-CREB (Ser 133) in RIPA lysates from forskolin treated rat PC-12 and mouse 3T3/A31 cells (Figure A).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-807,Anti-phospho-CREB (Ser133) Antibody, clone 634-2

上一件merck millipore产品：merck millipore,默克密理博,SF-1320,AFF3; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,14-777M,Plk1 Protein, active, 250 µg


相关产品

merck millipore,默克密理博,650366,Tryptase, Human Lung merck millipore,默克密理博,650366,Tryptase, Human Lung

merck millipore,默克密理博,70856,RNase A Solution merck millipore,默克密理博,70856,RNase A Solution

merck millipore,默克密理博,16-125,Protein A Agarose merck millipore,默克密理博,16-125,Protein A Agarose

merck millipore,默克密理博,407252,Insulin-Like Growth Factor-I, Mouse, Recombinant, E. coli merck millipore,默克密理博,407252,Insulin-Like Growth Factor-I, Mouse, Recombinant, E. coli

merck millipore,默克密理博,SF-1320,AFF3; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1320,AFF3; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,14-777M,Plk1 Protein, active, 250 µg merck millipore,默克密理博,14-777M,Plk1 Protein, active, 250 µg

merck millipore,默克密理博,MAB1149,Anti-Tie-2 Antibody, extracellular, clone 4G8HE merck millipore,默克密理博,MAB1149,Anti-Tie-2 Antibody, extracellular, clone 4G8HE

merck millipore,默克密理博,AB5860-200UL,Anti-Potassium Channel TREK-1 Antibody merck millipore,默克密理博,AB5860-200UL,Anti-Potassium Channel TREK-1 Antibody

merck millipore,默克密理博,ABN256,Anti-DMBT1 Antibody merck millipore,默克密理博,ABN256,Anti-DMBT1 Antibody

merck millipore,默克密理博,14-587,p38α/SAPK2a (6His-tag) Protein, active, 10 µg merck millipore,默克密理博,14-587,p38α/SAPK2a (6His-tag) Protein, active, 10 µg


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部