merck millipore,默克密理愽
  • merck millipore,默克密理博,05-773,Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal

  • merck millipore,默克密理博,05-773,Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal

    产品名称：Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal
    产品型号：05-773
    Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19 is an antibody against phospho-MYPT1 (Thr850) for use in WB.

    merck millipore,默克密理博,05-773,Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,05-773,Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, ChWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-773
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal
    产品信息
    格式 Purified
    应用
    应用 Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19 is an antibody against phospho-MYPT1 (Thr850) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide containing the sequence ...RS[pT]GV..., in which [pT] corresponds to phosphorylated threonine at amino acid residue 850 of chicken myosin phosphatase target subunit 1 (MYPT1). Corresponds to Thr853 in human MYPT1.
    克隆 SA19
    宿主 Rabbit
    特异性 MYPT1 phosphorylated on Thr850
    同种型 IgG
    品种反应性 HumanChicken
    Species Reactivity Note Predicted to cross react with mouse and rat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002480
    Entrez基因汇总 Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.
    基因符号
    • MBS
    • PPP1R12A
    • MYPT1
    • MGC133042
    修改
    • Phosphorylation
    纯化方法 Protein A purfied
    UniProt编号
    • O14974
    UniProt汇总 FUNCTION: SwissProt: O14974 # Regulates myosin phosphatase activity.
    SIZE: 1030 amino acids; 115281 Da
    SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16.
    SUBCELLULAR LOCATION: Cytoplasm. Note=Along actomyosin filaments and stress fibers.
    PTM: Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: O14974 ## Contains 6 ANK repeats.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on RIPA lysates from HEK293 cells phosphorylated by preincubation with ROKα/ROCK-II, active (Catalog # 14-338).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,05-773,Anti-phospho-MYPT1 (Thr850) Antibody, clone SA19, rabbit monoclonal

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