merck millipore,默克密理博,05-1570,Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	FC, WB, ELISA, IHC	R	Purified	Monoclonal Antibody

描述
产品目录编号	05-1570
描述	Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3
Alternate Names	PR domain zinc finger protein 1 PR domain containing 1, with ZNF domain PR-domain zinc finger protein 1 beta-interferon gene positive-regulatory domain I binding factor Positive regulatory domain I-binding factor 1 PRDI-binding factor-1 Beta-interferon gene positive regulatory domain I-binding factor B-lymphocyte-induced maturation protein 1 PR domain-containing protein 1 PRDI-binding factor 1
背景信息	B-lymphocyte induced maturation protein (BLIMP-1) is a 100 kDa transcriptional repressor containing 1 DET domain and 4 C2H2-type zinc fingers. In the nucleus, BLIMP-1 is known to bind specifically with the Beta-interferon gene positive regulatory domain I (PRDI), and to interact with PRMT5. During B-cell differentiation, BLIMP-1 actively represses the transcription of the gene, c-myc, through binding its promoter and has been deemed a “master regulator” for terminal B-cell differentiation, as it is able to initiate the BCL1 cell developmental cascade.

产品信息
格式	Purified
控制	HL-60 cell lysate
演示	Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Use Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 (Rat Monoclonal Antibody) validated in WB, ELISA, IHC, FC to detect PRDM1 (BLIMP-1) also known as PR-domain zinc finger protein 1.
主要应用	Flow Cytometry Western Blotting ELISA Immunohistochemistry
应用说明	ELISA Analysis: A representative lot was used by an independent laboratory in ELISA. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.) Flow Cytometry Analysis: A representative lot was used by an independent laboratory in FC. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)

生物信息
免疫原品种	Recombinant protein corresponding to mouse BLIMP-1.
表位	Recognizes epitope located between amino acids 255-395 of BLIMP-1
克隆	6D3
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
特异性	Recognizes BLIMP-1
同种型	IgG2aκ
品种反应性	MouseHuman
Species Reactivity Note	Demonstrated to react with human and mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_031574
基因符号	BLIMP-1 BLIMP1 PRDM1 PRDI-BF1
纯化方法	Protein G
UniProt编号	Q60636
UniProt汇总	FUNCTION: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. SUBUNIT STRUCTURE: Interacts with PRMT5. Ref.5 SUBCELLULAR LOCATION: Nucleus (By similarity). SEQUENCE SIMILARITIES: Contains 4 C2H2-type zinc fingers. Contains 1 SET domain. SEQUENCE CAUTION: The sequence AAI29802.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

产品使用声明
质量保证	Evaluated by Western Blot in HL-60 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected BLIMP-1 on 10 µg of HL-60 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,05-1570,Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3

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