merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1529,Anti-FXR1 Antibody, clone 6BG10

  • merck millipore,默克密理博,05-1529,Anti-FXR1 Antibody, clone 6BG10

    产品名称：Anti-FXR1 Antibody, clone 6BG10
    产品型号：05-1529
    Use Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.

    merck millipore,默克密理博,05-1529,Anti-FXR1 Antibody, clone 6BG10

  • 产品介绍
  • merck millipore,默克密理博,05-1529,Anti-FXR1 Antibody, clone 6BG10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1529
    描述 Anti-FXR1 Antibody, clone 6BG10
    Alternate Names
    • fragile X mental retardation-related protein 1
    • fragile X mental retardation, autosomal homolog 1
    背景信息 Fragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FXR1 in HeLa and NIH/3T3 cell lysates.

    Immunoprecipitation Analysis: A representative lot was used in an independent laboratory in immunoprecipitation. Siomi, M., et al. (1996). Molecular and Cellular Biology. 3825-3832.
    生物信息
    免疫原品种 Recombinant protein corresponding to human FXR1.
    表位 Unknown
    克隆 6BG10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes FXR1.
    同种型 IgG2aκ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001013456.1
    Entrez基因汇总 The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
    基因符号
    • hFXR1
    • FXR1
    纯化方法 Protein G purfied
    UniProt编号
    • P51114
    UniProt汇总 FUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs By similarity.

    SUBUNIT STRUCTURE: Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1.

    SUBCELLULAR LOCATION: Cytoplasm.

    TISSUE SPECIFICTY: Expressed in all tissues examined including heart, brain, kidney and testis.

    PTM: Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

    SEQUENCE SIMILARITIES: Belongs to the FMR1 family.

    Contains 2 KH domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/ml of this antibody detected FXR1 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1529,Anti-FXR1 Antibody, clone 6BG10

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