merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1049,Anti-Met (extracellular) Antibody, clone 4F8.2

  • merck millipore,默克密理博,05-1049,Anti-Met (extracellular) Antibody, clone 4F8.2

    产品名称：Anti-Met (extracellular) Antibody, clone 4F8.2
    产品型号：05-1049
    Detect Met (extracellular) using this Anti-Met (extracellular) Antibody, clone 4F8.2 validated for use in IH(P) & WB.

    merck millipore,默克密理博,05-1049,Anti-Met (extracellular) Antibody, clone 4F8.2

  • 产品介绍
  • merck millipore,默克密理博,05-1049,Anti-Met (extracellular) Antibody, clone 4F8.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1049
    Replaces 05-237
    描述 Anti-Met (extracellular) Antibody, clone 4F8.2
    Alternate Names
    • oncogene MET
    • HGF receptor
    • HGF/SF receptor
    • Met proto-oncogene tyrosine kinase
    • SF receptor
    • Scatter factor receptor
    • met proto-oncogene
    • met proto-oncogene (hepatocyte growth factor receptor)
    背景信息 The proto-oncogene Met (c-Met, HGF/SF Receptor, HGFR) is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. This stimulates the autophosphorylation on Tyr1234/Tyr1235 which leads to pleiotropic downstream signaling events in epithelial cells that stimulate multiple cellular processes including cell proliferation, growth, differentiation, cell migration/ invasion, and tumorigenesis. These effects are mediated by SH2 domain-containing proteins that bind to the C-terminal tail of c-Met. Chronic stimulation of Met on cancer cells is thought to play a role in metastasis and dysregulation of c-Met activity is directly associated with oncogenesis, making it an important cancer target.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal in 0.1M Tris-Glycine (pH7.4), 150mM NaCl with 0.05% NaN3.
    应用
    应用 Detect Met (extracellular) using this Anti-Met (extracellular) Antibody, clone 4F8.2 validated for use in IH(P) & WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis:
    This lot detected Met at 1:1,000 dilution in HEK293 cell lysate resolved via SDS-PAGE and transferred to PVDF.

    Immunohistochemistry Analysis :
    生物信息
    免疫原品种 GST-fusion protein corresponding to amino acids 80-434 of human Met.
    表位 Extracelluar domain (N-term)
    克隆 4F8.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Detects Met on its extracellular domain.
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001120972.1
    Entrez基因汇总 The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
    基因符号
    • c-Met
    • AUTS9
    • EC 2.7.10.1
    • HGFR
    • OTTHUMP00000069168
    • RCCP2
    纯化方法 Protein G purfied
    UniProt编号
    • P08581
    UniProt汇总 FUNCTION: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.

    Catalytic activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    SUBUNIT:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 By similarity. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction.

    LOCATION: Single-pass type I membrane protein.

    DOMAIN:The kinase domain is involved in SPSB1 binding.

    DISEASE: Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.

    Defects in MET may be associated with gastric cancer.

    Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].

    Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.

    Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.

    SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family.

    Contains 3 IPT/TIG domains.

    Contains 1 protein kinase domain.

    Contains 1 Sema domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot.

    Western Blot Analysis:
    This lot detected Met at 1:1,000 dilution in HEK293 cell lysate resolved via SDS-PAGE and transferred to PVDF.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1049,Anti-Met (extracellular) Antibody, clone 4F8.2

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