merck millipore,默克密理愽
  • merck millipore,默克密理博,04-805,Anti-SET7/9 Antibody, clone 5F2.3

  • merck millipore,默克密理博,04-805,Anti-SET7/9 Antibody, clone 5F2.3

    产品名称：Anti-SET7/9 Antibody, clone 5F2.3
    产品型号：04-805
    Use Anti-SET7/9 Antibody, clone 5F2.3 (Mouse Monoclonal Antibody) validated in WB to detect SET7/9 also known as Histone-lysine N-methyltransferase SETD7, Set7, Set9.

    merck millipore,默克密理博,04-805,Anti-SET7/9 Antibody, clone 5F2.3

  • 产品介绍
  • merck millipore,默克密理博,04-805,Anti-SET7/9 Antibody, clone 5F2.3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-805
    Replaces MABE529
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-SET7/9 Antibody, clone 5F2.3
    Alternate Names
    • Set9
    • SetD7
    • Histone-lysine N-methyltransferase SETD7
    • EC 2.1.1.43
    • SET domain-containing protein 7
    • SET7/9
    • Histone H3-K4 methyltransferase SETD7
    • Set7
    背景信息 The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of Histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule, in an unusual conformation, binds a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.
    产品信息
    格式 Purified
    演示 100 μg of protein G purified mouse IgG1κ in Tris-Glycine with 0.05% NaN3.
    应用
    应用 Use Anti-SET7/9 Antibody, clone 5F2.3 (Mouse Monoclonal Antibody) validated in WB to detect SET7/9 also known as Histone-lysine N-methyltransferase SETD7, Set7, Set9.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 N-terminal His-tagged human SET9 recombinant protein
    表位 N-terminal region
    克隆 5F2.3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes human SET7/9
    品种反应性 RatHumanMouse
    Species Reactivity Note Not yet tested in other species.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • AAL69901
    UniProt编号
    • Q8WTS6
    UniProt汇总 FUNCTION: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

    SUBUNIT: Interacts with IPF1/PDX-1.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Widely expressed. Expressed in pancreatic islets.

    DOMAIN: The SET domain is necessary but not sufficient for histone methyltransferase activity.

    MISCELLANEOUS: Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction.
    产品使用声明
    质量保证 Routinely evaluated by western blot on RIPA lysates from NIH/3T3 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-805,Anti-SET7/9 Antibody, clone 5F2.3

上一件merck millipore产品：merck millipore,默克密理博,ABE210,Anti-TRF1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,422426,KGF/FGF-7, Mouse, Recombinant


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