merck millipore,默克密理愽
  • merck millipore,默克密理博,04-771,Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

  • merck millipore,默克密理博,04-771,Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

    产品名称：Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal
    产品型号：04-771
    Anti-Akt2/PKBβ Antibody, clone AW114 detects level of Akt2/PKBβ & has been published & validated for use in WB & IP.

    merck millipore,默克密理博,04-771,Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-771,Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-771
    Replaces 04-406
    描述 Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal
    Alternate Names
    • v-akt murine thymoma viral oncogene homolog 2
    • AKT2 kinase
    • Murine thymoma viral (v-akt) homolog-2
    • PKB beta
    • Protein kinase Akt-2
    • Protein kinase B, beta
    • rac protein kinase beta
    背景信息 Akt is the major known effector of the PI3 Kinase pathway. Generation of PIP3 results in the activation of PDK1, which phosphorylates Akt on Thr308, and another kinase complex, thought to be the mTORC2 complex (or possibly an intermediate kinase linking the two) that phosphorylates Akt on Ser473. These phosphorylations additively activate Akt Ser/Thr kinase activity, and the use of phosphorylation state-specific antibodies directed against either of these sites can imply Akt activation. Activation of Akt can be measured directly by immunoprecipitation followed by phosphorylation of a known substrate with radiolabeled ATP. Akt has been shown to phosphorylate over 70 substrates including TSC1&2 in the mTOR pathway, Bad on Ser136, GSK3 (which is inactivated by this phosphorylation), and the FoxO family of transcription factors (PRAS40, AS160).
    产品信息
    格式 Purified
    控制
    • L6 cell lysate
    演示 Cultured supernantant containing 0.05% sodium azide.
    应用
    应用 Anti-Akt2/PKBβ Antibody, clone AW114 detects level of Akt2/PKBβ & has been published & validated for use in WB & IP.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide (CRYDSLGSLELDQRTH) corresponding to amino acids 455-469 of human Akt2/PKBβ, with an N-terminal cysteine added for conjugation purposes.
    表位 a.a. 455-469
    克隆 AW114
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Akt2/PKBβ, Mr ~60 kDa.
    同种型 IgG
    品种反应性 RatHumanMouse
    Species Reactivity Note Human and rat. Predicted to cross-react with mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001617.1
    Entrez基因汇总 This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
    基因符号
    • RAC-PK-beta
    • EC 2.7.11.1
    • PKBB
    • PKBBETA
    • PRKBB
    • RAC-BETA
    UniProt编号
    • P31751
    UniProt汇总 FUNCTION: General protein kinase capable of phosphorylating several known proteins.
    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
    ENZYME REGULATION:Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.
    SUBUNIT STRUCTURE: Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B.
    TISSUE SPECIFICITY:In all human cell types so far analyzed.
    INVOLVEMENT IN DISEASE: Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.
    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Western Blot Analysis: A 1:500 dilution of this antibody detected Akt2/PKBβ in HepG2 lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µl

    merck millipore,默克密理博,04-771,Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

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