merck millipore,默克密理愽
  • merck millipore,默克密理博,04-278,Anti-HePTP (PTPN7) Antibody, clone D24

  • merck millipore,默克密理博,04-278,Anti-HePTP (PTPN7) Antibody, clone D24

    产品名称：Anti-HePTP (PTPN7) Antibody, clone D24
    产品型号：04-278
    Anti-HePTP (PTPN7) Antibody, clone D24 detects level of HePTP (PTPN7) & has been published & validated for use in WB.

    merck millipore,默克密理博,04-278,Anti-HePTP (PTPN7) Antibody, clone D24

  • 产品介绍
  • merck millipore,默克密理博,04-278,Anti-HePTP (PTPN7) Antibody, clone D24

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-278
    商名
    • Upstate
    描述 Anti-HePTP (PTPN7) Antibody, clone D24
    Alternate Names
    • Protein tyrosine phosphatase, non-receptor type 7
    • Protein tyrosine phosphatase
    产品信息
    格式 Purified
    控制
    • Jurkat cell lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing PBS with 0.1% sodium azide.
    应用
    应用 Anti-HePTP (PTPN7) Antibody, clone D24 detects level of HePTP (PTPN7) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis: 0.5-2 µg/mL of this lot was used to detect HePTP(PTPN7) in Jurkat cell lysates.
    生物信息
    免疫原品种 Full length recombinant His-tag protein.
    克隆 D24
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes HePTP (PTPN7) at ~38-40 kDa.
    同种型 IgG2bκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002823
    Entrez基因汇总 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
    基因符号
    • LC-PTP
    • PTPN7
    • HePTP
    • LPTP
    • PTPNI
    • BPTP-4
    纯化方法 Protein G purfied
    UniProt编号
    • P35236
    UniProt汇总 FUNCTION: Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
    CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
    SUBCELLULAR LOCATION: Cytoplasm.
    ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.
    TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen.
    PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
    SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
    SEQUENCE CAUTION: Sequence=AAA59531.1; Type=Frameshift; Positions=5;
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-278,Anti-HePTP (PTPN7) Antibody, clone D24

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