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merck millipore,默克密理博,04-259,Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18
产品名称：Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18
产品型号：04-259
Detect 19S regulator non-ATPase subunit S5a/Rpn10 using this Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18 validated for use in IP & WB.
merck millipore,默克密理博,04-259,Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-259 品牌系列 Upstate
商名 - Upstate
描述 Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18 概述 Rpn10 (S5a) is a non-ATPase subunit of the 19S regulatory complex of the 26s proteasome. Subunit Rpn10 (S5a) of the 26S proteasome was originally identified as a protein capable of binding poly-ubiquitin chains of four or more ubiquitins, in the absence of other 26S proteasome subunits. Alternate Names - S5a
产品信息 格式 Purified 演示 100 µL of purified immunoglobulin in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4. 应用 应用 Detect 19S regulator non-ATPase subunit S5a/Rpn10 using this Anti-19S regulator non-ATPase subunit S5a/Rpn10 Antibody, clone S5a-18 validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full length human recombinant Rpn10 protein. 克隆 S5a-18 宿主 Mouse 特异性 Recognizes 19S regulator non-ATPase subunit S5a/Rpn10. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002810.2
- NM_153822.2
Entrez基因汇总 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. 基因符号 - ASF
- PSMD4
- pUB-R5
- OTTHUMP00000059963
- Rpn10
- AF-1
- AF
- MCB1
- S5A
UniProt编号 - P55036
UniProt汇总 FUNCTION: SwissProt: P55036 # Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.
SIZE: 377 amino acids; 40737 Da
SUBUNIT: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Directly interacts with NUB1. Interacts with SQSTM1.
DOMAIN: SwissProt: P55036 The 2 UIM motifs are involved in the binding to a multi- ubiquitin chain in a cooperative way.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the proteasome subunit S5A family. & Contains 2 UIM (ubiquitin-interacting motif) repeats. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of shipment for up to 12 months. 包装信息 数量 100 µL
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