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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-139 商名 - Upstate
描述 Anti-Plakoglobin Antibody, clone 15F11 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing PBS and 0.05% sodium azide. 应用 应用 This Anti-Plakoglobin Antibody, clone 15F11 is validated for use in WB for the detection of Plakoglobin. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant protein of plakoglobin. 克隆 clone 15F11 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes human plakoglobin. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002221
Entrez基因汇总 This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq]. 基因符号 - DP3
- JUP
- CTNNG
纯化方法 Protein G purfied UniProt编号 - P14923
UniProt汇总 FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
SUBUNIT: Homodimer. Interacts with MUC1.
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form.
DISEASE: Defects in JUP are the cause of Naxos disease [MIM:601214]. Naxos disease is an autosomal recessive disorder combining non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular cardiomyopathy and woolly hair.
DISEASE: Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
SIMILARITY: Belongs to the beta-catenin family.
SIMILARITY: Contains 9 ARM repeats.
SEQUENCE CAUTION:
Sequence=AAH00441.2; Type=Erroneous initiation; Note=Translation N-terminally shortened
WEB RESOURCE: Name=GeneReviews.产品使用声明 质量保证 Routinely evaluated by western blotting on HeLa cell lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB15452,Anti-MAP2 Antibody
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