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  • merck millipore,默克密理博,01-305,PDGF-BB Protein, human

  • merck millipore,默克密理博,01-305,PDGF-BB Protein, human

    产品名称：PDGF-BB Protein, human
    产品型号：01-305
    The human PDGF-BB Protein is available in a 10 µg format.

    merck millipore,默克密理博,01-305,PDGF-BB Protein, human

  • 产品介绍
  • merck millipore,默克密理博,01-305,PDGF-BB Protein, human

    重要规格表

    主要应用 品种 来源
    CULTHumanRecombinant protein expressed in E.coli from the c-sis oncogene.
    描述
    产品目录编号 01-305
    品牌系列 Upstate
    商名
    • Upstate
    描述 PDGF-BB Protein, human
    产品信息
    演示 Lypholized from 0.1M acetic acid
    应用
    应用 The human PDGF-BB Protein is available in a 10 µg format.
    主要应用
    • Cell Culture
    生物信息
    来源 Recombinant protein expressed in E.coli from the c-sis oncogene.
    品种 Human
    Entrez基因编号
    • NM_033016.1
    • NM_002608.1
    Entrez基因汇总 The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.
    基因符号
    • Becaplermin
    • PDGFB
    • FLJ12858
    • PDGF2
    • becaplermin
    • SIS
    • c-sis
    • PDGF-2
    • SSV
    物理形式 Lyophilized
    纯化方法 Sterilized through a 0.2 micron membrane filter
    UniProt编号
    • P01127
    UniProt汇总 FUNCTION: SwissProt: P01127 # Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
    SIZE: 241 amino acids; 27283 Da
    SUBUNIT: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with XLKD1 (By similarity).
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
    DISEASE: SwissProt: P01127 # A chromosomal aberration involving PDGFB is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with COLA1. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities.
    SIMILARITY: SwissProt: P01127 ## Belongs to the PDGF/VEGF growth factor family.
    MISCELLANEOUS: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.
    产品使用声明
    质量保证 Routinely evaluated by biological activity assay.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,01-305,PDGF-BB Protein, human

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下一件merck millipore产品：merck millipore,默克密理博,196811,Bax-Inhibiting Peptide, Negative Control - Calbiochem


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