merck millipore,默克密理博,382185,HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,382185,HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem

经验配方	CAS号
C₂₀H₂₆N₂O₂S₂	848354-66-5

描述
概述	A cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA's hydroxamate as the active-site zinc-targeting group. NCH-51 is shown to exhibit comparable antiproliferative (mean IC₅₀ = 3.8 µM vs. 3.7 µM for SAHA; 48 h treatment) and apoptotic activity as SAHA against various cancer cell lines, but not PBMCs from 4 healthy individuals (IC₅₀ >30 µM with either drug), and the antioxidant N-Acetyl-L-Cysteine (NAC; Cat. No. 106425) at 2 mM is reported to abolish the cell-growth inhibition caused by either 3 µM NCH-51 or SAHA in the Multiple Myeloma U266 cultures. Half-life in human plasma at 37 °C = 24 h.
产品目录编号	382185
品牌系列	Calbiochem®
同义词	Thioisobutyric acid (S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester

参考
参考	Sanda, T., et al. 2007. Leukemia 21, 2344. Suzuki, T., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1558. Suzuki, T., et al. 2005. J. Med. Chem. 48, 1019.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,382185,HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem

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