merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1440,Anti-phospho-Paxillin (Tyr118) Antibody

  • merck millipore,默克密理博,07-1440,Anti-phospho-Paxillin (Tyr118) Antibody

    产品名称：Anti-phospho-Paxillin (Tyr118) Antibody
    产品型号：07-1440
    Detect phospho-Paxillin (Tyr118) using this Anti-phospho-Paxillin (Tyr118) Antibody validated for use in WB.

    merck millipore,默克密理博,07-1440,Anti-phospho-Paxillin (Tyr118) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1440,Anti-phospho-Paxillin (Tyr118) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1440
    Replaces AB3837
    描述 Anti-phospho-Paxillin (Tyr118) Antibody
    背景信息 Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Tyr118 phosphorylation of paxillin occurs in response to focal adhesion kinase (FAK).
    产品信息
    格式 Affinity Purified
    控制
    • L6 cell lysate
    演示 Purified rabbit polyclonal antibody in buffer containing 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
    应用
    应用 Detect phospho-Paxillin (Tyr118) using this Anti-phospho-Paxillin (Tyr118) Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugagted synthetic peptide corresponding to human Paxillin phosphorylated at Tyr118.
    表位 Tyr118
    宿主 Rabbit
    特异性 This antibody recognizes Paxillin phosphorylated at Tyr118.
    品种反应性 RatHumanMouse
    Species Reactivity Note Reacts with rat, human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000935.1
    基因符号
    • paxillin
    • FLJ16691
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P49023
    UniProt汇总 FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
    SUBUNIT STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
    SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
    PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    SEQUENCE SIMILARITIES: Belongs to the paxillin family.
    Contains 4 LIM zinc-binding domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in L6 cell lysate.
    Western Blot Analysis: A 1:1000 dilution of this antibody detected Paxillin on 10 µg of L6 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1440,Anti-phospho-Paxillin (Tyr118) Antibody

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