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Replacement Information Replacement Information 07-1219 is a recommended replacement for AB4086 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1219 Replaces AB4086 描述 Anti-PP2A Antibody, B β subunit Alternate Names - Serine/threonine protein phosphatase 2A, catalytic subunit, beta<br />isoform
- Serine/Threonine Protein Phosphatase PP2A-BETA, Catalytic Subunit
- Serine/Threonine-protein Phosphatase 2A catalytic subunit beta<br />isoform
- Protein Phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
- Protein phosphatase 2, catalytic subunit, beta isoform
- protein phosphatase type 2A catalytic subunit
- beta isoform
- Protein phosphatase 2
- protein phosphatase type 2A catalytic subunit
- Serine/threonine protein phosphatase 2A
背景信息 PP2A is a heterotrimeric type 2 Ser/Thr phosphatase, composed of a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B'/PR61, and B''/PR72 . The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variants derived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. PTPA is a member of the B' family that is required for activation of PP2A by an undefined mechanism. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 Cell Lysate
演示 Purified rabbit polyclonal IgG provided as 0.2 µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide. 应用 应用 Anti-PP2A Antibody, B β subunit detects level of PP2A & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
生物信息 免疫原品种 The immunogen used to the purified peptide conjugated to KLH corresponding to the sequence NH2-Cys-Gly-Glu-Glu-Asp-Ile-Asp-THr-Arg- Lys-Ile-Asn-Asn-Ser-Phe-COOH. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Protein Phosphatase 2A/B. Minimal cross reactivity against 2A/B. 同种型 IgG 品种反应性 RatBovineHumanMouse Species Reactivity Note Bovine,Human, Mouse, Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001009552
Entrez基因汇总 The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12. 基因符号 - EC 3.1.3.16
- PPP2CB
- PP2CB
- PP2A-beta
纯化方法 Affinity Purfied UniProt编号 - P62714
UniProt汇总 FUNCTION: SwissProt: Q00005 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
SIZE: 443 amino acids; 51710 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
TISSUE SPECIFICITY: Brain.
DISEASE: SwissProt: Q00005 # Defects in PPP2R2B are the cause of spinocerebellar ataxia 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The molecular defect in SCA12 is the expansion of a CAG repeat in the 5'-UTR of the gene.
SIMILARITY: SwissProt: Q00005 ## Belongs to the phosphatase 2A regulatory subunit B family. & Contains 7 WD repeats. ... hide » see more »产品使用声明 质量保证 Routinely evaluated by Western Blot on NIH/3T3 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP2A/B BETA on 10 μg of NIH/3T3 lysates.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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