merck millipore,默克密理愽
  • merck millipore,默克密理博,05-457,Anti-Histone H1 Antibody, clone AE-4

  • merck millipore,默克密理博,05-457,Anti-Histone H1 Antibody, clone AE-4

    产品名称：Anti-Histone H1 Antibody, clone AE-4
    产品型号：05-457
    Use Anti-Histone H1 Antibody, clone AE-4 (mouse monoclonal antibody) validated in ELISA, ICC, WB to detect Histone H1 also known as H1 histone family member 4, Histone H1b, histone 1 H1e, histone clus More>>

    merck millipore,默克密理博,05-457,Anti-Histone H1 Antibody, clone AE-4

  • 产品介绍
  • merck millipore,默克密理博,05-457,Anti-Histone H1 Antibody, clone AE-4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Pl, H, BWB, ELISA, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-457
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Histone H1 Antibody, clone AE-4
    Alternate Names
    • histone cluster 1, H1e
    • H1 histone family, member 4
    • Histone H1b
    • histone 1, H1e
    • histone 1
    • H1e
    背景信息 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
    产品信息
    格式 Purified
    控制
    • Nuclear extracts from NIH3T3 or HeLa cells.
    演示 Purified mouse monoclonal IgG2a in buffer containing PBS, pH 7.2, with 0.1% sodium azide. Frozen solution.
    应用
    应用 Use Anti-Histone H1 Antibody, clone AE-4 (mouse monoclonal antibody) validated in ELISA, ICC, WB to detect Histone H1 also known as H1 histone family member 4, Histone H1b, histone 1 H1e, histone cluster 1 H1e.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    应用说明 Immunocytochemistry:
    5-20 µg/mL of a previous lot showed positive nuclear immunostaining in A431 cells fixed with 4% paraformaldehyde and methanol.

    ELISA:
    Recommended.
    生物信息
    免疫原品种 Nuclei from myeloid leukemia biopsy cells. Clone AE-4.
    克隆 AE-4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes histone H1, Mr 32-33 kDa. Doublet detected due to hyperphosphorylation of histone H1 subpopulation. Cross-reacts with other histone isoforms in the following order of signal strength: H3, H2B > H4 > H2A, as determined with recombinant protein.
    同种型 IgG2a
    品种反应性 Green PlantsHumanBovine
    Species Reactivity Note Human and bovine. Predicted to stain nuclei from other animal and plant species.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005322
    Entrez基因汇总 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
    基因符号
    • MGC116819
    • HIST1H1E
    • H1F4
    • H1.4
    • dJ221C16.5
    纯化方法 Protein G purfied
    UniProt编号
    • P10412
    UniProt汇总 FUNCTION: SwissProt: P10412 # Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
    SIZE: 219 amino acids; 21865 Da
    SUBCELLULAR LOCATION: Nucleus.
    SIMILARITY: SwissProt: P10412 ## Belongs to the histone H1/H5 family.
    MISCELLANEOUS: This variant accounts for 60% of histone H1.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on lysates from an acid extract of HeLa cells.

    Western Blot:
    1-4 µg/mL of this lot detected histone H1 in lysates from an acid extract of HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.

    Handling Recommendations:
    Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-457,Anti-Histone H1 Antibody, clone AE-4

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