merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1075,Anti-FOXO1 Antibody, clone 2H8.2

  • merck millipore,默克密理博,05-1075,Anti-FOXO1 Antibody, clone 2H8.2

    产品名称：Anti-FOXO1 Antibody, clone 2H8.2
    产品型号：05-1075
    Use Anti-FOXO1 Antibody, clone 2H8.2 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC(P) to detect FOXO1 also known as Forkhead box protein O1A, Forkhead in rhabdomyosarcoma.

    merck millipore,默克密理博,05-1075,Anti-FOXO1 Antibody, clone 2H8.2

  • 产品介绍
  • merck millipore,默克密理博,05-1075,Anti-FOXO1 Antibody, clone 2H8.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1075
    Replaces 04-1005
    描述 Anti-FOXO1 Antibody, clone 2H8.2
    Alternate Names
    • forkhead, Drosophila, homolog of, in rhabdomyosarcoma
    • Forkhead box protein O1A
    • Forkhead in rhabdomyosarcoma
    • forkhead box O1
    • forkhead box O1A (rhabdomyosarcoma)
    • forkhead homolog in rhabdomyosarcoma
    背景信息 Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Gross, D.N., 2009).
    产品信息
    格式 Purified
    控制
    • HEK293 cell lysate
    演示 Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-FOXO1 Antibody, clone 2H8.2 (Mouse Monoclonal Antibody) validated in WB, ICC, IHC(P) to detect FOXO1 also known as Forkhead box protein O1A, Forkhead in rhabdomyosarcoma.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry: A 1:500 dilution of a previous lot was used.

    Immunocytochemistry: Representative lot data.
    A 1:500 dilution of a previous lot was used.

    Immunohistochemistry (Paraffin): Representative lot data.
    Optimal Staining With Epitope Retrieval: Ductal Carcinoma In Situ.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to full length FOXO1.
    克隆 2H8.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody detects FOXO1.
    FOXO1 shuttles between the nucleus and the cytosol.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, mouse and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002006.2
    Entrez基因汇总 This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq].
    基因符号
    • OTTHUMP00000018301
    • FKH1
    • FKHR
    • FOXO1A
    纯化方法 Protein G purfied
    UniProt编号
    • Q12778
    UniProt汇总 FUNCTION: Transcription factor.
    SUBUNIT STRUCTURE: Interacts with LRPPRC By similarity.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Shuttles between cytoplasm and nucleus.
    TISSUE SPECIFICITY: Ubiquitous.
    PTM: Phosphorylated by AKT1; insulin-induced By similarity. IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.
    INVOLVEMENT IN DISEASE: Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.
    SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by western blot on HEK293 cell lysate.
    Western Blot Analysis: 2 µg/mL of this antibody detected FOXO1 in HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-1075,Anti-FOXO1 Antibody, clone 2H8.2

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