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merck millipore,默克密理博,MABS385,Anti-APOL1 Antibody, clone 1D4
产品名称：Anti-APOL1 Antibody, clone 1D4
产品型号：MABS385
Detect Apolipoprotein using this mouse monoclonal antibody, Anti-APOL1 Antibody & clone 1D4 validated for use in western blotting.
merck millipore,默克密理博,MABS385,Anti-APOL1 Antibody, clone 1D4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Ascites Monoclonal Antibody 描述 产品目录编号 MABS385 描述 Anti-APOL1 Antibody, clone 1D4 Alternate Names - Apolipoprotein L-I
- APOL
- APO-L
- APOL-I
- Apolipoprotein L1
- Apolipoprotein L
背景信息 Apolipoprotein L1/Apolipoprotein L-1 (ApoL-1), or alternatively Apolipoprotein L (Apo-L/ApoL) is the protein encoded by the APOL1 gene in humans. Apolipoprotein L1 is one of the major carriers of cholesterol in the blood. It plays a role in the transport of cholesterol from the peripheral cells to the liver. It is a secreted protein expressed in liver, pancreas, lung, prostate, placenta and spleen. Apolipoprotein L1 is part of the HDL (high density lipoprotein) complex and Apolipoprotein L1 possesses both extra- and intra-cellular functions crucial in host defense and cellular homeostatic mechanisms. Alterations in Apolipoprotein L1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD), yet much of its biological function remains unknown. Interesting, Apolipoprotein L1 has the ability to kill circulating trypanosomes in the blood. Trypanosomes cause a serious disease called sleeping sickness but in those individuals that have particular splice variants of Apolipoprotein L1 are spared sleeping sickness, however the variants are associated with an increased chance of kidney disease as a tradeoff. Apolipoprotein L1 appears important in autophagy and even as a cancer preventative as well. Recent research shows that increased intracellular levels of Apolipoprotein L1 can induce autophagy and autophagy-associated cell death but that Apolipoprotein L1 may protect kidney cells against renal cell carcinoma.
产品信息 格式 Ascites 控制 - Human plasma lysate
演示 Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide. 应用 应用 Detect Apolipoprotein using this mouse monoclonal antibody, Anti-APOL1 Antibody & clone 1D4 validated for use in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 Purified recombinant fragment of human APOL1 expressed in E. Coli. 克隆 1D4 宿主 Mouse 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - APOL-I
- APOL
- APO-L
纯化方法 Unpurified UniProt编号 - O14791
产品使用声明 质量保证 Evaluated by Western Blotting in human plasma.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected APOL1 in human plasma.
Optimal working dilutions must be determined by end user.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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