merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS146,Anti-RasGRP1 Antibody, clone 10.1

  • merck millipore,默克密理博,MABS146,Anti-RasGRP1 Antibody, clone 10.1

    产品名称：Anti-RasGRP1 Antibody, clone 10.1
    产品型号：MABS146
    Detect RasGRP1 using this mouse monoclonal antibody, Anti-RasGRP1 Antibody & clone 10.1 validated for use in western blotting.

    merck millipore,默克密理博,MABS146,Anti-RasGRP1 Antibody, clone 10.1

  • 产品介绍
  • merck millipore,默克密理博,MABS146,Anti-RasGRP1 Antibody, clone 10.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS146
    描述 Anti-RasGRP1 Antibody, clone 10.1
    Alternate Names
    • Ras guanyl-releasing protein
    • RAS guanyl-releasing protein 1
    • Calcium and DAG-regulated guanine nucleotide exchange factor II
    • CalDAG-GEFII
    背景信息 RasGRP1, also known as Calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII) or Ras guanyl-releasing protein (RASGRP), and encoded by the gene RASGRP1/RASGRP, functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. RasGRP1 activates the Erk/MAP kinase cascade and couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, it regulates T-cells and B-cells development, homeostasis and differentiation. Additionally, RasGRP1 functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. RasGRP1 may also function in other cell types’ differentiation. RasGRP1 is localized to the cytoplasm and cell membrane; it is a peripheral membrane protein in the Golgi/ER membranes. In neurons, RasGRP1 localizes to somata and dendrites but not to axons of hippocampal pyramidal cells of in the brain and in particular the cerebellum, cortex and amygdata. RasGRP1 also is expressed in the hematopoietic system including T cells and RasGRP1 is also found expressed developmentally in fetal brain and kidney tissues. Defects in RasGRP1 may be associated with Systemic lupus erythematosus (SLE) a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Interestingly it is thought that aberrantly spliced isoforms or other mutations of RASGRP1 give rise to dysregulation of various signaling processes which in turn contribute to the development of autoimmunity in SLE patients.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect RasGRP1 using this mouse monoclonal antibody, Anti-RasGRP1 Antibody & clone 10.1 validated for use in western blotting.
    主要应用
    • Western Blotting
    应用说明 Western Blotting Analysis: 1.0 µg/mL from a representative lot detected RasGRP1 in 10 µg of human cerebellum tissue lysate.
    Flow Cytometry Analysis: A representative lot detected RasGRP1 in malignant lymphoid cells treated with tipifarmib (Ding, H., et al. (2011). Blood. 118:4872-4881).
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human RasGRP1.
    克隆 10.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001122074
    基因符号
    • RASGRP
    • RASGRP1
    纯化方法 Protein G purified
    UniProt编号
    • O95267
    产品使用声明
    质量保证 Evaluated by Western Blotting in MOLT-4 cell lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected RasGRP1 in 10 µg of MOLT-4 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS146,Anti-RasGRP1 Antibody, clone 10.1

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