merck millipore,默克密理博,MABC48,Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABC48
描述	Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10
Alternate Names	anterior gradient 2 homolog (Xenopus laevis) anterior gradient homolog 2 (Xenopus laevis) anterior gradient 2 homolog protein disulfide isomerase family A, member 17 Secreted cement gland protein XAG-2 homolog anterior gradient protein 2 homolog secreted cement gland homolog
背景信息	Anterior gradient protein 2 homolog (AGR2) (also known as secreted cement gland protein XAG-2 homolog) is thought to be a metastasis-inducing protein in breast cancer models and may be used as a means of detecting the outcome of hormonally treated patients with breast cancer. AGR2 may also play an important role in intestinal mucus production. Recent researched has also linked AGR2 to metastasis. Lower levels of AGR expression in prostate cancer may be highly predictive of the reoccurrence of disease even after a prostatectomy.

产品信息
格式	Purified
控制	MCF-7 cell lysate
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10 is an antibody against Anterior gradient protein 2 homolog for use in WB & IC.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC on primary carcinomas (Barraclough, D., et al. (2009). Am J Pathol. 175:1848–1857).

生物信息
免疫原品种	Linear peptide corresponding to a sequence unique to human Anterior gradient protein 2 homolog and not to human Anterior gradient protein 3 homolog.
克隆	7A10
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Specific for Anterior gradient protein 2 homolog and does not detect Anterior gradient protein 3 homolog.
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_006399
基因符号	hAG-2 AGR2 GOB-4 AG2 HAG-2 XAG-2 PDIA17 AG-2 HPC8
纯化方法	Protein G Purified
UniProt编号	O95994
UniProt汇总	FUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. SUBUNIT STRUCTURE: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum (By similarity). TISSUE SPECIFICTY: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. SEQUENCE SIMILARITIES: Belongs to the AGR family.

产品使用声明
质量保证	Evaluated by Western Blot in MCF-7 cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABC48,Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10

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