- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC R Purified Monoclonal Antibody 描述 产品目录编号 MABC12 描述 Anti-TRAIL Antibody, clone N2B2 Alternate Names - TRAIL
- Tumor necrosis factor ligand superfamily member 10
- TNF-related apoptosis-inducing ligand
- Protein TRAIL
- CD253
背景信息 Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (1,2). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-5). Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. 产品信息 格式 Purified 控制 - 2PK-3 cells
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-TRAIL Antibody, clone N2B2 detects level of TRAIL & has been published & validated for use in Flow Cytometry. 主要应用 - Flow Cytometry
应用说明 Flow Cytometry Analysis: A representative lot was used by an independent laboratory in B6 splenocytes. (Kayagaki, N., et al. (1996). J Immunol. 163:1906-1913.) 生物信息 免疫原品种 Mouse TRAIL transfectant 表位 Extracellular domain 克隆 N2B2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 This antibody recognizes TRAIL at the extracellular domain. 同种型 IgG2aκ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_033451
基因符号 - Tnfsf10
- TRAIL
- Trail
纯化方法 Protein G purified UniProt编号 - P50592
UniProt汇总 FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
SUBUNIT STRUCTURE: Homotrimer (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein Potential.
TISSUE SPECIFICITY: Widespread.
SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.产品使用声明 质量保证 Evaluated by Flow Cytometry in 2PK-3 cells.
Flow Cytometry Analysis: 0.2 µg of this antibody detected TRAIL in 2PK-3 cells.销售限制 Not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,ST1571,Anti-FCGR2A Mouse mAb (3E8)
下一件merck millipore产品：merck millipore,默克密理博,442615,Magnesium Chloride, Hexahydrate - CAS 7791-18-6 - Calbiochem
相关产品
merck millipore,默克密理博,MAB5268-K,Mouse Anti-Chromogranin A, clone LK2H10 (2) (1mg)
merck millipore,默克密理博,14-441M,Fyn Protein, active, 250 µg
merck millipore,默克密理博,14-523,JNK3/SAPK1b Protein, unactive, 50 µg
merck millipore,默克密理博,ST1571,Anti-FCGR2A Mouse mAb (3E8)
merck millipore,默克密理博,442615,Magnesium Chloride, Hexahydrate - CAS 7791-18-6 - Calbiochem
merck millipore,默克密理博,PP63-K,IgG, Rabbit Gamma Globulin (1gm)
merck millipore,默克密理博,05-1579,Anti-Axin-1 Antibody, clone A5
merck millipore,默克密理博,MABE918,Anti-Brd4 Antibody, clone 1F11
merck millipore,默克密理博,PSRP010R1,Millicell-24 插入式细胞培养板, PET, 1.0 µm