- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MAB3745,Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10
产品名称：Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10
产品型号：MAB3745
Detect Natural Killer Cell Receptor-P1 using this Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10 validated for use in IP & WB.
merck millipore,默克密理博,MAB3745,Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3745 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10 Alternate Names - NKR-P1
背景信息 Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in phosphate buffered saline and 0.08% sodium azide. 应用 应用 Detect Natural Killer Cell Receptor-P1 using this Anti-Natural Killer Cell Receptor-P1 Antibody, clone 1C10 validated for use in IP & WB. 主要应用 - Western Blotting
应用说明 Western blot (1-5 μg/ml)
Immunoprecipitation
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cellline. 克隆 1C10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes mouse NKR-P1 cells. Binds to NKR-P1 receptors and induces release of cytokine in SJL/J NK cells. 同种型 IgG1 品种反应性 Mouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002258.2
Entrez基因汇总 Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. 基因符号 - CD161
- KLRB1
- hNKR-P1A
- MGC138614
- NKRP1A
- NKR-P1
- NKR-P1A
- NKR
- HNKR-P1a
- CLEC5B
UniProt编号 - Q12918
UniProt汇总 FUNCTION: SwissProt: Q12918 # Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
SIZE: 225 amino acids; 25415 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
PTM: N-glycosylated. Contains sialic acid residues.
SIMILARITY: SwissProt: Q12918 ## Contains 1 C-type lectin domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MABF358,Anti-CD45RO (human) Antibody, PE/Cy5, clone UCHL1
下一件merck millipore产品：merck millipore,默克密理博,MAB1616,Anti-Kinesin Antibody, light chain, clone L1
相关产品
merck millipore,默克密理博,SF-1712,HSP90AB1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MAB8140-KC,Mouse Anti-Cytomegalovirus Early (1mg) KC
merck millipore,默克密理博,AP124A,Goat Anti-Mouse IgG Antibody, Alkaline Phosphatase conjugate
merck millipore,默克密理博,MABF358,Anti-CD45RO (human) Antibody, PE/Cy5, clone UCHL1
merck millipore,默克密理博,MAB1616,Anti-Kinesin Antibody, light chain, clone L1
merck millipore,默克密理博,04-1112,Anti-Neurofilament-L (CT) Antibody, clone EP675Y, rabbit monoclonal
merck millipore,默克密理博,16-200,Anti-Histidine Tagged Antibody, clone 4D11, biotin conjugate
merck millipore,默克密理博,SF-1101,miR-320-3p; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare