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merck millipore,默克密理博,MAB3152,Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10
产品名称：Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10
产品型号：MAB3152
Detect Cardiac Troponin I using this Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10 validated for use in ELISA & WB.
merck millipore,默克密理博,MAB3152,Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Fe, B, Ca, Gt, H, Po, Rb WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3152 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10 Alternate Names - Cardiac Troponin I
- cTn1
产品信息 格式 Purified 演示 Liquid in PBS (pH 7.4) with 0.1% sodium azide. 应用 应用 Detect Cardiac Troponin I using this Anti-Cardiac Troponin I Antibody, a.a. 87-91, clone 8E10 validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blotting: identifies two bands 14kDa and 18kDa which appear to be breakdown products of full length cTn1 (Morjana N. 1998, Degradation of human cardiac troponin I after myocardial infarction. Biotechnol Appl. Biochem. 28:105-11).
EIA: MAB3152 has been used successfully in ELISA and immunoaffinity purification. Its affinity constant is 8x10(10). It can be used with MAB3150 in sandwhich ELISA as the coating antibody.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Free human cardiac troponin 1. 表位 a.a. 87-91 克隆 8E10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 MAB3152 reacts equally with free cardiac troponin 1 (cTn1) and cTn1 forming complexes with other troponin components. It recognizes epitopes that are not perturbed or sterically shielded by other troponin components. Not affected by heparin, phosphorylation, oxidation and complex formation. Recognizes an epitope located between amino acid residues 87 and 91 of cTnI. There is no cross-reaction with skeletal muscle troponin 1. 同种型 IgG1 品种反应性 FelineBovineCanineGoatHumanPigRabbit 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000363.4
Entrez基因汇总 Troponin I (TnI) is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle; see also TNNI1 (MIM 191042). The others are troponin T (TnT; see MIM 191041) and troponin C (TnC; see MIM 191040).[supplied by OMIM] 基因符号 - cTnI
- TNNI3
- TNNC1
- CMH7
- MGC116817
非反应性品种 - Fish
- Mouse
- Rat
UniProt编号 - P19429
UniProt汇总 FUNCTION: SwissProt: P19429 # Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
SIZE: 210 amino acids; 24008 Da
SUBUNIT: Binds to actin and tropomyosin. Interacts with TRIM63.
DISEASE: SwissProt: P19429 # Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:191044]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with a high risk of cardiac failure and sudden cardiac death. & Defects in TNNI3 are the cause of familial restrictive cardiomyopathy (RCM) [MIM:115210]. RCM is an heart muscle disorder characterized by impaired filling of the ventricles with reduced volume in the presence of normal or near normal wall thickness and systolic function. The disease may be associated with systemic disease but is most often idiopathic.
SIMILARITY: SwissProt: P19429 ## Belongs to the troponin I family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 100 µg
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