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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB2620 描述 Anti-Beta-parvin Antibody, clone 11A5 Alternate Names - affixin
- parvin beta
- parvin-beta
背景信息 Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILK-binding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007). 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Beta-parvin Antibody, clone 11A5 is validated for use in WB, IC for the detection of Beta-parvin. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution detected Beta-parvin in NIH/3T3 and HeLa cells. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human Beta-parvin. 表位 Unknown 克隆 11A5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_037459.2
Entrez基因汇总 Members of the parvin family, including PARVB, are actin-binding proteins associated with focal contacts.[supplied by OMIM]. 基因符号 - CGI-56
- PARVB
纯化方法 Protein G purfied UniProt编号 - Q9HBI1
UniProt汇总 FUNCTION: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.
SUBUNIT STRUCTURE: Interacts with DYSF. Interacts with integrin-linked protein kinase and actin.
SUBCELLULAR LOCATION: Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Note: Constituent of focal adhesions.
TISSUE SPECIFICITY: Expressed predominantly in heart and skeletal muscle.
SEQUENCE SIMILARITIES: family.
Contains 2 CH (calponin-homology) domains.
SEQUENCE CAUTION: 34051.1 differs from that shown. Reason: Frameshift at positions 4, 14, 48, 58, 155, 162, 171, 327, 331 and 344.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Beta-parvin in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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