merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1098,Anti-Tumor Necrosis Factor-β Antibody, clone 9B9

  • merck millipore,默克密理博,MAB1098,Anti-Tumor Necrosis Factor-β Antibody, clone 9B9

    产品名称：Anti-Tumor Necrosis Factor-β Antibody, clone 9B9
    产品型号：MAB1098
    Anti-Tumor Necrosis Factor-β Antibody, clone 9B9 detects level of Tumor Necrosis Factor-β & has been published & validated for use in IC, IH & WB.

    merck millipore,默克密理博,MAB1098,Anti-Tumor Necrosis Factor-β Antibody, clone 9B9

  • 产品介绍
  • merck millipore,默克密理博,MAB1098,Anti-Tumor Necrosis Factor-β Antibody, clone 9B9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1098
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tumor Necrosis Factor-β Antibody, clone 9B9
    Alternate Names
    • TNF-beta
    产品信息
    格式 Purified
    演示 Purified immunoglobulin (Protein A-agarose chormotography). One bottle of lyophilized preparation contains:200ug mouse IgG, 2 mg potassium phosphate buffer, 2.9 mg sodium chloride, and 20 mg raffinose.Reconstitution with 1 ml sterile, distilled water results in an antibody concentration of 200 ug/ml.
    应用
    应用 Anti-Tumor Necrosis Factor-β Antibody, clone 9B9 detects level of Tumor Necrosis Factor-β & has been published & validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Western blot

    Immunocytochemistry

    Immunohistochemistry

    Neutralization: 200ng of TNF-beta antibody is required for the neutralizaion of 1 unit/ml TNF-beta. The TNF-beta-preparation which is used has a specific activity of ca. 2x10(7) units/mg protein [cell lytic assay with L 929 cells (mouse transformed fibroblasts) and/or WEHJ 164 cells (mouse fibrosarcoma cells)/actinomycin D] .

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human, recombinant tumor necrosis factor-beta (TNF-beta, lymphotoxin) produced in E. Coli.
    克隆 9B9
    宿主 Mouse
    特异性 This antibody is use for detection, identification and neutralixzation of TNF-b in cell culture and other biological samples. The antibody reacts with human natural and recombinant TNF-b (lymphotoxin). It does not react with human TNF-a. Determination of cross-reactivity to TNF-b from other species has not been done.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000595.2
    Entrez基因汇总 Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
    基因符号
    • TNFSF1
    • LTA
    • OTTHUMP00000037612
    • TNF-beta
    • OTTHUMP00000037613
    • LT-alpha
    • LT
    • TNFB
    UniProt编号
    • P01374
    UniProt汇总 FUNCTION: SwissProt: P01374 # Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
    SIZE: 205 amino acids; 22297 Da
    SUBUNIT: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
    SUBCELLULAR LOCATION: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
    DISEASE: SwissProt: P01374 # Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae. & Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.
    SIMILARITY: SwissProt: P01374 ## Belongs to the tumor necrosis factor family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months.Freeze only once.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,MAB1098,Anti-Tumor Necrosis Factor-β Antibody, clone 9B9

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