merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1048,Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1

  • merck millipore,默克密理博,MAB1048,Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1

    产品名称：Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1
    产品型号：MAB1048
    Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1 detects level of Bone Morphogenetic Protein 6 & has been published & validated for use in IH(P).

    merck millipore,默克密理博,MAB1048,Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1

  • 产品介绍
  • merck millipore,默克密理博,MAB1048,Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HIH(P)MPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1048
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1
    Alternate Names
    • vgr-1 (vegetal related)
    • BMP-6
    • DVR-6 (Decapentaplegic Vegetal Related)
    背景信息 Bone morphogenetic protein 6 (BMP6) is a polypetide that is a member of the TGF-β superfamily of proteins. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
    产品信息
    格式 Purified
    控制
    • Embryonic and adult central nervous system, rat radial glial cells, fetal intestine, healing skin or chondrocytes
    演示 Purified immunoglobulin from culture supernatant. Lyophilized from PBS containing 5 mg/mL BSA and 0.09% sodium azide. Reconstitute with 0.5 mL of sterile distilled water.
    应用
    应用 Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1 detects level of Bone Morphogenetic Protein 6 & has been published & validated for use in IH(P).
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry: 1-5 μg/mL. Fixation: formaldehyde, paraffin. Tissue pretreatment: microwave treatment (6 x 5) min is required.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide vgr 1-29C-KLH.
    克隆 Morph-6.1
    宿主 Mouse
    特异性 Bone morphogenetic protein 6 (BMP-6) is a member of the TGF-b superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis. MAB1048 recognizes BMP-6. Pre-incubation of MAB1048 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the monoclonal to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as irrelevant peptides does not inhibit specific tissue staining. The antigen is highly conserved phylogenetically and is thus anticipated to react with most mammalian species.
    同种型 IgG1
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001718.4
    Entrez基因汇总 The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
    基因符号
    • VGR
    • BMP6
    • VGR1
    • BMP-6
    UniProt编号
    • P22004
    UniProt汇总 FUNCTION: SwissProt: P22004 # Induces cartilage and bone formation.
    SIZE: 513 amino acids; 57226 Da
    SUBUNIT: Interacts with SOSTDC1 (By similarity).
    SUBCELLULAR LOCATION: Secreted (By similarity).
    SIMILARITY: SwissProt: P22004 ## Belongs to the TGF-beta family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at 2-8°C for up to 12 months after date of receipt. After reconstitution maintain at -20*C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1048,Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1

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