• merck millipore,默克密理博,GLP1A-35HK,Glucagon Like Peptide-1 (Active) RIA
  • merck millipore,默克密理博,GLP1A-35HK,Glucagon Like Peptide-1 (Active) RIA

    产品名称:Glucagon Like Peptide-1 (Active) RIA
    产品型号:GLP1A-35HK
    This radioimmunoassay (RIA) measures & quantifies Glucagon Like Peptide-1 for use in Metabolism & Endocrine research.

    merck millipore,默克密理博,GLP1A-35HK,Glucagon Like Peptide-1 (Active) RIA

  • 产品介绍
  • merck millipore,默克密理博,GLP1A-35HK,Glucagon Like Peptide-1 (Active) RIA

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    Glucagon Like Peptide-1R, H, MRIA125I, Radioactive
    描述
    产品目录编号 GLP1A-35HK
    描述 Glucagon Like Peptide-1 (Active) RIA
    背景信息 GLP-1 is secreted from gut endocrine cells in response to nutrient ingestion and plays multiple roles in metabolic homeostasis.
    产品信息
    检测方法 125IRadioactive
    性能
    • ED 20 = 241 ± 24 pM
    • ED80 = 28 ± 7 pM
    • ED50 = 82 ± 10 pM
    精度(%)
    • Intra-assay: 26.5 ± 4.7
    • Inter-assay: 26.7 ± 12.7
    应用
    应用 This radioimmunoassay (RIA) measures & quantifies Glucagon Like Peptide-1 for use in Metabolism & Endocrine research.
    主要应用
    • Radioimmunoassay
    应用说明 Two-day disequilibrium assay at 4°C. Sample volume = 300 μL plasma (extraction required)
    生物信息
    品种反应性 RatHumanMouse
    可用的分析物
    • Glucagon Like Peptide-1
    交叉反应性 GLP-1 is conserved in almost all mammals. This kit may be used to measure GLP-1 in these samples (e.g. rat, mouse, etc.)
    Entrez基因编号
    • NM_002054.2
    Entrez基因汇总 The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
    基因符号
    • GLP2
    • GCG
    • GLP1
    • glucagon
    • GRPP
    标签 125I-GLP-1
    UniProt编号
    • P01275
    UniProt汇总 FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
    SIZE: 180 amino acids; 20909 Da
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
    PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
    SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
    MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
    准确度
    • 40.7 ± 2.9%
    理化信息
    标准曲线范围
    • 10–500 pM
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 125 tubes

    merck millipore,默克密理博,GLP1A-35HK,Glucagon Like Peptide-1 (Active) RIA

上一件merck millipore产品:merck millipore,默克密理博,123041,AICA-Riboside, 5ʹ-Phosphate - CAS 3031-94-5 - Calbiochem
下一件merck millipore产品:merck millipore,默克密理博,S8000,CpGenome™ Universal Methylated Mouse DNA Standard Set



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